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Table 2 Univariable and multivariable analysis to identify predictors of disease-free survival of HCC patients after radical resection

From: Individual and joint influence of cytokeratin 19 and microvascular invasion on the prognosis of patients with hepatocellular carcinoma after hepatectomy

Variable

Univariable

Multivariable

HR

95% CI

P

HR

95% CI

P

Lower

Upper

Lower

Upper

Age (years)

0.992

0.978

1.006

0.271

    

Sex (male/female)

0.756

0.487

1.174

0.231

    

BCLC stage (0/A/B)

1.637

1.224

2.189

0.001

1.018

0.609

1.703

0.994

HBsAg (negative/positive)

2.266

1.259

4.078

0.006

1.984

1.020

3.861

0.044

HBV-DNA (< 5 × 102IU/ml/≧5 × 102IU/ml)

1.656

1.179

2.325

0.004

1.398

0.945

2.068

0.094

Anti-HCV (negative/positive)

1.326

0.544

3.233

0.535

    

Tumor diameter (cm)

1.115

1.068

1.164

< 0.001

1.060

1.007

1.116

0.026

Tumor number (1/≥2)

2.041

1.482

2.809

< 0.001

1.685

0.974

2.918

0.062

Tumor envelope (complete/incomplete)

1.067

0.721

1.580

0.746

    

Ascites (negative/positive)

1.289

0.808

2.056

0.287

    

AFP (<400 ng/ml/≥400 ng/ml)

1.450

1.071

1.963

0.016

1.207

0.877

1.660

0.249

WBC (*109/L)

1.049

0.972

1.131

0.219

    

N% (%)

1.020

1.004

1.037

0.014

1.009

0.976

1.044

0.583

L% (%)

0.975

0.958

0.993

0.008

0.997

0.960

1.035

0.869

HB (g/L)

1.001

0.992

1.010

0.853

    

PLT (*109/L)

1.000

0.998

1.002

0.909

    

FPG (mmol/L)

1.081

0.985

1.185

0.099

    

PT (s)

0.902

0.789

1.030

0.128

    

INR

0.619

0.170

2.251

0.467

    

TBiL (μmol/L)

0.982

0.958

1.007

0.150

    

Alb (g/L)

0.964

0.931

0.997

0.033

0.988

0.948

1.030

0.584

PA (mg/L)

0.996

0.994

0.998

0.001

0.988

0.995

1.000

0.081

ALT (U/L)

0.998

0.994

1.003

0.485

    

AST (U/L)

1.000

0.996

1.004

0.954

    

GGT (U/L)

1.001

1.000

1.002

0.042

1.001

0.999

1.002

0.548

ALP (U/L)

1.004

1.002

1.006

0.001

1.002

0.999

1.005

0.146

CK19 (negative/positive)

1.437

1.021

2.022

0.038

1.604

1.100

2.337

0.014

MVI (negative/positive)

1.518

1.119

2.057

0.007

1.365

0.987

1.887

0.060

  1. Abbreviations: AFP alpha fetoprotein, Alb albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, anti-HCV antibodies against hepatitis C virus, AST aspartate aminotransferase; BCLC Barcelona Clinic liver cancer, CK19 cytokeratin 19, FPG fasting plasma glucose, GGT γ-glutamyl transpeptidase, HB hemoglobin, HBsAg hepatitis B surface antigen, INR international normalized ratio, L% lymphocyte percentage, N% neutrophil percentage, MVI microvascular invasion; PA prealbumin, PLT blood platelets, PT prothrombin time, TBiL total bilirubin, WBC white blood cells