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Table 2 Univariable and multivariable analysis to identify predictors of disease-free survival of HCC patients after radical resection

From: Individual and joint influence of cytokeratin 19 and microvascular invasion on the prognosis of patients with hepatocellular carcinoma after hepatectomy

Variable Univariable Multivariable
HR 95% CI P HR 95% CI P
Lower Upper Lower Upper
Age (years) 0.992 0.978 1.006 0.271     
Sex (male/female) 0.756 0.487 1.174 0.231     
BCLC stage (0/A/B) 1.637 1.224 2.189 0.001 1.018 0.609 1.703 0.994
HBsAg (negative/positive) 2.266 1.259 4.078 0.006 1.984 1.020 3.861 0.044
HBV-DNA (< 5 × 102IU/ml/5 × 102IU/ml) 1.656 1.179 2.325 0.004 1.398 0.945 2.068 0.094
Anti-HCV (negative/positive) 1.326 0.544 3.233 0.535     
Tumor diameter (cm) 1.115 1.068 1.164 < 0.001 1.060 1.007 1.116 0.026
Tumor number (1/≥2) 2.041 1.482 2.809 < 0.001 1.685 0.974 2.918 0.062
Tumor envelope (complete/incomplete) 1.067 0.721 1.580 0.746     
Ascites (negative/positive) 1.289 0.808 2.056 0.287     
AFP (<400 ng/ml/≥400 ng/ml) 1.450 1.071 1.963 0.016 1.207 0.877 1.660 0.249
WBC (*109/L) 1.049 0.972 1.131 0.219     
N% (%) 1.020 1.004 1.037 0.014 1.009 0.976 1.044 0.583
L% (%) 0.975 0.958 0.993 0.008 0.997 0.960 1.035 0.869
HB (g/L) 1.001 0.992 1.010 0.853     
PLT (*109/L) 1.000 0.998 1.002 0.909     
FPG (mmol/L) 1.081 0.985 1.185 0.099     
PT (s) 0.902 0.789 1.030 0.128     
INR 0.619 0.170 2.251 0.467     
TBiL (μmol/L) 0.982 0.958 1.007 0.150     
Alb (g/L) 0.964 0.931 0.997 0.033 0.988 0.948 1.030 0.584
PA (mg/L) 0.996 0.994 0.998 0.001 0.988 0.995 1.000 0.081
ALT (U/L) 0.998 0.994 1.003 0.485     
AST (U/L) 1.000 0.996 1.004 0.954     
GGT (U/L) 1.001 1.000 1.002 0.042 1.001 0.999 1.002 0.548
ALP (U/L) 1.004 1.002 1.006 0.001 1.002 0.999 1.005 0.146
CK19 (negative/positive) 1.437 1.021 2.022 0.038 1.604 1.100 2.337 0.014
MVI (negative/positive) 1.518 1.119 2.057 0.007 1.365 0.987 1.887 0.060
  1. Abbreviations: AFP alpha fetoprotein, Alb albumin, ALP alkaline phosphatase, ALT alanine aminotransferase, anti-HCV antibodies against hepatitis C virus, AST aspartate aminotransferase; BCLC Barcelona Clinic liver cancer, CK19 cytokeratin 19, FPG fasting plasma glucose, GGT γ-glutamyl transpeptidase, HB hemoglobin, HBsAg hepatitis B surface antigen, INR international normalized ratio, L% lymphocyte percentage, N% neutrophil percentage, MVI microvascular invasion; PA prealbumin, PLT blood platelets, PT prothrombin time, TBiL total bilirubin, WBC white blood cells