Characteristic | CK19(−) | CK19(+) | P | MVI(−) | MVI(+) | P | CK19(−)/MVI(−) | CK19(−)/MVI(+) | CK19(+)/MVI(−) | CK19(+)/MVI(+) | P |
---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | 49.94 ± 10.51 | 46.76 ± 11.64 | 0.020 | 49.59 ± 10.80 | 48.75 ± 10.91 | 0.469 | 50.18 ± 10.48 | 49.62 ± 10.57 | 46.71 ± 12.04 | 46.78 ± 11.52 | 0.134 |
Sex | |||||||||||
 Male | 227 (84.1%) | 67 (81.7%) | 0.613 | 151 (81.6%) | 143 (85.6%) | 0.319 | 126 (81.8%) | 101 (87.1%) | 25 (80.6%) | 42 (82.4%) | 0.654 |
 Female | 43 (15.9%) | 15 (18.3%) | 34 (18.4%) | 24 (14.4%) | 28 (18.2%) | 15 (12.9%) | 6 (19.4%) | 9 (17.6%) | |||
BCLC stage | |||||||||||
 0 | 10 (3.7%) | 5 (6.1%) | 0.238 | 12 (6.5%) | 3 (1.8%) | 0.086 | 7 (4.5%) | 3 (2.6%) | 5 (16.1%) | 0 (0%) | 0.003 |
 A | 181 (67.0%) | 60 (73.2%) | 122 (65.9%) | 119 (71.3%) | 105 (68.2%) | 76 (65.5%) | 17 (54.8%) | 43 (84.3%) | |||
 B | 79 (29.3%) | 17 (20.7%) | 51 (27.6%) | 45 (26.9%) | 42 (27.3%) | 37 (31.9%) | 9 (29.0%) | 8 (15.7%) | |||
HBsAg | |||||||||||
 Negative | 35 (13.0%) | 11 (13.4%) | 1.000 | 20 (10.8%) | 26 (15.6%) | 0.207 | 16 (10.4%) | 19 (16.4%) | 4 (12.9%) | 7 (13.7%) | 0.549 |
 Positive | 235 (87.0%) | 71 (86.6%) | 165 (89.2%) | 141 (84.4%) | 138 (89.6%) | 97 (83.6%) | 27 (87.1%) | 44 (86.3%) | |||
HBV-DNA (IU/ml) | |||||||||||
  < 5 × 102 | 90 (33.3%) | 32 (39.0%) | 0.356 | 63 (34.1%) | 59 (35.3%) | 0.823 | 51 (33.1%) | 39 (33.6%) | 12 (38.7%) | 20 (39.2%) | 0.823 |
 ≧5 × 102 | 180 (66.7%) | 50 (61.0%) | 122 (65.9%) | 108 (64.7) | 103 (66.9%) | 77 (66.4%) | 19 (61.3%) | 31 (60.8%) | |||
Anti-HCV | |||||||||||
 Negative | 266 (98.5%) | 80 (97.6%) | 0.627 | 182 (98.4%) | 164 (98.2%) | 1.000 | 152 (98.7%) | 114 (98.3%) | 30 (96.8%) | 50 (98.0%) | 0.896 |
 Positive | 4 (1.5%) | 2 (2.4%) | 3 (1.6%) | 3 (1.8%) | 2 (1.3%) | 2 (1.7%) | 1 (3.2%) | 1 (2.0%) | |||
Tumor diameter (cm) | 5.00 (3.50, 7.50) | 4.75 (3.5, 8.00) | 0.383 | 4.50 (3.50, 7.00) | 5.50 (3.50, 8.50) | 0.008 | 4.75 (3.50, 7.00) | 6.00 (3.50, 8.50) | 4.00 (2.5, 6.00) | 5.00 (3.50, 10.00) | 0.017 |
Tumor number | |||||||||||
 1 | 193 (71.5%) | 65 (79.3%) | 0.200 | 140 (75.7%) | 118 (70.7%) | 0.335 | 117 (76.0%) | 76 (65.5%) | 23 (74.2%) | 42 (82.4%) | 0.098 |
 ≧2 | 77 (28.5%) | 17 (20.7%) | 45 (24.3%) | 49 (29.3%) | 37 (24.0%) | 40 (34.5%) | 8 (25.8%) | 9 (17.6%) | |||
Tumor envelope | |||||||||||
 Complete | 230 (85.2%) | 66 (80.5%) | 0.305 | 164 (88.6%) | 132 (79.0%) | 0.019 | 134 (87.0%) | 96 (82.8%) | 30 (96.8%) | 36 (70.6%) | 0.008 |
 Incomplete | 40 (14.8%) | 16 (19.5%) | 21 (11.4%) | 35 (21.0%) | 20 (13.0%) | 20 (17.2%) | 1 (3.2%) | 15 (29.4%) | |||
Ascites | |||||||||||
 No | 249 (92.2%) | 73 (89.0%) | 0.370 | 170 (91.9%) | 152 (91.0%) | 0.849 | 143 (92.9%) | 106 (91.4%) | 27 (87.1%) | 46 (90.2%) | 0.742 |
 Yes | 21 (7.8%) | 9 (11.0%) | 15 (8.1%) | 15 (9.0%) | 11 (7.1%) | 10 (8.6%) | 4 (12.9%) | 5 (9.8%) | |||
AFP (ng/ml) | |||||||||||
 <400 | 180 (66.7%) | 31 (37.8%) | < 0.001 | 129 (69.7%) | 82 (49.1%) | < 0.001 | 115 (74.7%) | 65 (56.0%) | 14 (45.2%) | 17 (33.3%) | < 0.001 |
  ≥ 400 | 90 (33.3%) | 51 (62.2%) | 56 (30.3%) | 85 (50.9%) | 39 (25.3%) | 51 (44.0%) | 17 (554.8%) | 34 (66.7%) | |||
WBC (*109/L) | 6.06 (4.88, 7.22) | 5.40 (4.55, 6.80) | 0.050 | 5.73 (4.66, 7.12) | 6.06 (4.91, 7.16) | 0.246 | 5.94 (4.74, 7.26) | 6.17 (5.13, 7.16) | 5.18 (4.55, 6.48) | 5.73 (4.53, 7.31) | 0.094 |
N% (%) | 57.91 ± 9.96 | 57.17 ± 9.96 | 0.557 | 56.95 ± 9.87 | 58.61 ± 10.01 | 0.118 | 57.21 ± 9.96 | 58.83 ± 9.93 | 55.45 ± 9.42 | 58.09 ± 10.26 | 0.352 |
L% (%) | 29.93 ± 8.47 | 30.05 ± 9.06 | 0.910 | 30.24 ± 8.72 | 29.64 ± 8.48 | 0.510 | 30.09 ± 8.49 | 29.72 ± 8.47 | 31.03 ± 9.87 | 29.45 ± 8.57 | 0.855 |
HB (g/L) | 137.02 ± 17.20 | 140.01 ± 17.43 | 0.170 | 135.28 ± 17.43 | 140.43 ± 16.74 | 0.005 | 134.30 ± 17.08 | 140.64 ± 16.75 | 140.13 ± 18.63 | 139.94 ± 16.85 | 0.012 |
PLT (*109/L) | 209.92 ± 77.74 | 198.43 ± 81.61 | 0.247 | 208.52 ± 83.84 | 205.82 ± 72.79 | 0.749 | 211.92 ± 85.27 | 207.25 ± 66.72 | 191.61 ± 75.35 | 202.57 ± 85.66 | 0.585 |
FPG (mmol/L) | 4.71 (4.31, 5.22) | 4.73 (4.28, 5.14) | 0.792 | 4.76 (4.31, 5.22) | 4.66 (4.30, 5.16) | 0.326 | 4.74 (4.29, 5.22) | 4.68 (4.33, 5.22) | 4.84 (4.40, 5.24) | 4.65 (4.23, 5.10) | 0.605 |
PT (s) | 13.09 ± 1.11 | 13.31 ± 1.25 | 0.131 | 13.19 ± 1.11 | 13.09 ± 1.19 | 0.435 | 13.17 ± 1.07 | 12.99 ± 1.15 | 13.29 ± 1.30 | 13.32 ± 1.24 | 0.280 |
INR | 1.06 ± 0.12 | 1.07 ± 0.13 | 0.441 | 1.06 ± 0.12 | 1.06 ± 0.12 | 0.804 | 1.06 ± 0.12 | 1.06 ± 0.12 | 1.08 ± 0.14 | 1.07 ± 0.12 | 0.838 |
TBiL (μmol/L) | 11.40 (8.38, 15.53) | 11.30 (8.10, 14.83) | 0.549 | 11.00 (8.10, 15.30) | 11.60 (8.70, 15.30) | 0.402 | 10.90 (8.10, 15.23) | 11.75 (9.40, 16.58) | 13.20 (8.10, 16.20) | 11.20 (8.10, 13.80) | 0.359 |
Alb (g/L) | 41.08 ± 4.28 | 42.12 ± 4.45 | 0.056 | 41.16 ± 4.01 | 41.50 ± 4.48 | 0.453 | 40.91 ± 3.87 | 41.31 ± 4.78 | 42.40 ± 4.49 | 41.95 ± 4.47 | 0.220 |
PA (mg/L) | 197.50 (156.75, 244.25) | 192.00 (139.00, 247.00) | 0.610 | 203.00 (157.00, 243.00) | 191.00 (150.00, 249.00) | 0.691 | 198.50 (157.50, 242.00) | 195.50 (154.75, 255.25) | 218.00 (139.00, 257.00) | 180.00 (139.00, 233.00 ) | 0.555 |
ALT (U/L) | 34.50 (24.00, 47.00) | 30.50 (22.00, 39.00) | 0.099 | 33.00 (22.00, 45.50) | 33.00 (24.00, 44.00) | 0.936 | 32.50 (22.00, 46.00) | 36.50 (24.25, 47.75) | 34.00 (22.00, 41.00) | 30.00 (22.00, 39.00) | 0.196 |
AST (U/L) | 36.00 (27.00, 49.00) | 33.00 (25.50, 45.25) | 0.195 | 33.00 (25.50, 46.00) | 36.00 (29.00, 52.00) | 0.032 | 35.00 (26.00, 47.00) | 37.00 (29.00, 53.75) | 29.00 (23.00, 40.00) | 35.00 (28.00, 48.00) | 0.047 |
GGT (U/L) | 53.00 (33.00, 104.00) | 54.00 (31.75, 91.75) | 0.692 | 50.00 (29.00, 92.00) | 57.00 (36.00, 105.00) | 0.026 | 51.00 (30.00, 96.50) | 57.00 (36.00, 109.00) | 43.00 (26.00, 74.00) | 57.00 (36.00, 104.00) | 0.125 |
ALP (U/L) | 63.00 (50.00, 81.00) | 61.00 (45.00, 84.25) | 0.638 | 59.00 (45.00, 78.50) | 66.00 (53.00, 88.00) | 0.016 | 59.50 (47.00, 78.00) | 67.00 (55.25, 92.75) | 56.00 (42.00, 85.00) | 64.00 (48.00, 84.00) | 0.085 |
MVI | |||||||||||
 Negative | 154 (57.0%) | 31 (37.8%) | 0.002 | ||||||||
 Positive | 116 (43%) | 51 (62.2%) |