Table 4 Cox regression analyses of patient OS and DFS
Univariate and multivariate Cox regression analysis of predictors of OS and DFS | ||||||||
|---|---|---|---|---|---|---|---|---|
Variables | Overall survival | Disease-free survival | ||||||
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Surgical approach: robotic surgery vs laparoscopic surgery | 1.016 (0.654–1.579) | 0.943 | NA | NA | 0.979 (0.668-1.434) | 0.914 | NA | NA |
Age ≥70 years | 1.477 (0.932–2.340) | 0.097 | 1.592 (1.028–2.648) | 0.037 | 0.382 (0.911–2.098) | 0.128 | NA | NA |
Gender: male vs female | 1.117 (0.749–1.667) | 0.587 | NA | NA | 1.252 (0.881–1.778) | 0.21 | 1.548 (1.001–2.023) | 0.05 |
Neoadjuvant chemoradiotherapy | 1.133 (0.672–1.908) | 0.639 | NA | NA | 1.475 (0.945–2.303) | 0.087 | NA | NA |
Anastomotic leakage | 1.717 (0.801–3.680) | 0.165 | NA | NA | 1.557 (0.738–3.283) | 0.245 | NA | NA |
R1 resection | 3.594 (0.689–18.759) | 0.129 | NA | NA | 3.197 (0.686–14.899) | 0.139 | NA | NA |
Positive CRM | 8.292 (1.938–35.490) | 0.004 | 14.637 (4.547–47.123) | <0.0001 | 6.274 (1.641–23.994) | 0.007 | 10.416 (3.261–33.266) | <0.0001 |
T stage: pT1-3 vs pT4a | 2.111 (1.425–3.128) | <0.0001 | 1.884 (1.327–2.674) | 0.001 | 1.574 (1.131–2.191) | 0.007 | 1.515 (1.136–2.019) | 0.005 |
N stage: pN0 vs pN+ | 1.521 (1.357–1.705) | <0.0001 | 1.534 (1.387–1.697) | <0.0001 | 1.382 (1.251–1.527) | <0.0001 | 1.411 (1.287–1.548) | <0.0001 |
Postoperative adjuvant chemotherapy | 1.877 (0.878–4.015) | 0.104 | NA | NA | 1.203 (0.610–2.372) | 0.593 | NA | NA |
Postoperative adjuvant radiotherapy | 0.843 (0.546–1.300) | 0.439 | NA | NA | 0.751 (0.514–1.098) | 0.139 | NA | NA |