Fig. 4

Functional analysis and somatic mutation characterization between two subtypes. A GO analysis of differentially expressed genes between clusters 1 and 2. B GSEA showed that hallmarks of cancer progression are differentially enriched in cluster 2. C and D Oncoplots of the top 10 mutated genes in clusters 1 (C) and 2 (D). E Forest plot of the differentially mutated genes between clusters 1 and 2. *p < 0.05, **p < 0.01, and ***p < 0.001