Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection

Table 2 The correlation between C20orf54 protein expression and clinicopathologic factors in ESCC

Characteristics	n	C20orf54 protein expression (%)		P value
Characteristics	n	−/+	++/+++	P value
Age (years)^a
< 62	56	49 (87.5)	7 (12.5)	0.799
≥62	90	80 (88.89)	10 (11.11)	0.799
Gender
Male	104	93 (89.42)	11 (10.58)	0.728
Female	42	36 (85.71)	6 (14.29)	0.728
Differentiation^b
Well	32	28 (87.50)	4 (12.50)	0.014^*
Moderate	84	71 (84.53)	13 (15.48)
Poor	30	30 (100)	0
L/N metastasis
Negative	82	68 (82.93)	14 (17.07)	0.021^*
Positive	64	61 (95.31)	4 (4.69)	0.021^*
TNM stage^c
I/II	95	83 (87.37)	12 (12.63)	0.612
III/IV	51	46 (90.20)	5 (9.80)	0.612
Tumor location
Upper + middle	94	85 (90.43)	9 (9.57)	0.295
Lower	52	44 (84.62)	8 (15.38)	0.295
Invasion depth
Tis,T1	6	3 (50)	3 (50)	0.019^*
T2,T3,T4	140	126 (90)	14 (10)	0.019^*
Smoking status
Non-smokers	60	52 (86.67)	8 (13.33)	0.595
Smokers	86	77 (89.53)	9 (10.47)	0.595
Drinking status
Non-drinkers	82	71 (86.58)	11 (13.42)	0.450
Drinkers	64	58 (90.63)	6 (9.37)	0.450

L/N lymph node metastasis. ^aMean age. ^bHistologic grade was based on a World Health Organization classification published in 2019 [16]. ^cTNM stage was based on the American Joint Committee on Cancer Q1 criteria published in 2017 [14]

ISSN: 1477-7819