Construction and validation of immune-related LncRNAs classifier to predict prognosis and immunotherapy response in laryngeal squamous cell carcinoma

Table 2 Univariable and multivariable Cox regression analysis for prediction of survival in GEO database

Dataset	Factors	Subgroup	Univariable analysis		Multivariable analysis
Dataset	Factors	Subgroup	HR (95% CI)	P	HR (95% CI)	P
GSE65858	Age		0.92 (0.86–0.99)	0.024*	0.98 (0.92–1.05)	0.536
	Sex	Female	1
	Sex	Male	0.28 (0.14–0.56)	0.000*	0.28 (0.03–2.82)	0.280
	Smoking history	No	1
	Smoking history	Yes	0.29 (0.02–3.92)	0.348	NA	NA
	Alcohol history	No	1
	Alcohol history	Yes	0.74 (0.12–4.55)	0.743	NA	NA
	Pack years		1.02 (0.97–1.06)	0.457	NA	NA
	HPV status	Negative	1
	HPV status	Positive	0.12 (0.08–35.24)	0.933	NA	NA
	Clinical T	T1-T2	1
	Clinical T	T3-T4	1.12 (0.36–3.52)	0.952	NA	NA
	Clinical N	N0	1
	Clinical N	N1-N3	1.31 (0.80–2.12)	0.514	NA	NA
	Clinical stage	I-II	1
	Clinical stage	III-IV	1.06 (0.72–2.54)	0.952	NA	NA
	Treatment modalities	Mono-treatment	1
	Treatment modalities	Multi-treatment	1.44 (0.29–7.18)	0.654	NA	NA
	IRL score		1.32 (1.06–1.74)	0.003*	1.6 8 (1.44–2.42)	0.004*
GSE27020	Age		1.02 (0.99–1.06)	0.193	NA	NA
	Sex	Female	1
	Sex	Male	21.94 (0.34–32.16)	0.377	NA	NA
	Smoking history	No	1
	Smoking history	Yes	20.53 (0.06–28.44)	0.679	NA	NA
	Alcohol history	No	1
	Alcohol history	Yes	1.17 (0.58–2.33)	0.664	NA	NA
	Tumor grade	G1-G2	1
	Tumor grade	G3-G4	0.90 (0.64–1.26)	0.998	NA	NA
	Clinical stage	I-II	1
	Clinical stage	III-IV	1.00 (0.61–1.65)	0.525	NA	NA
	Radiation therapy	Yes			NA	NA
	Radiation therapy	No	2.22 (0.98–4.99)	0.055	NA	NA
	IRL score		1.92 (1.42–2.61)	0.000*	1.92 (1.42–2.61)	0.000*

These variables were eliminated in the multivariate cox regression model, so the HR and p-values were not available
HR hazard ratio, CI confidence intervals, NA not available
*p < 0.05

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