Table 1 Univariable and multivariable Cox regression analysis for prediction of survival in TCGA database
Factors | Subgroup | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age |  | 1.00 (0.97–1.04) | 0.984 | NA | NA |
Sex | Female | 1 | Â | Â | Â |
Male | 0.28 (0.14–0.56) | 0.000* | 0.31 (0.11–0.88) | 0.028* | |
Smoking history | No | 1 | Â | Â | Â |
Yes | 0.65 (0.35–1.18) | 0.156 | NA | NA | |
Alcohol history | No | 1 | Â | Â | Â |
Yes | 0.77 (0.43–1.39) | 0.388 | NA | NA | |
Number of lymph nodes |  | 1.00 (0.98–1.01) | 0.558 | NA | NA |
Number of positive LNs |  | 1.00 (0.95–1.04) | 0.892 | NA | NA |
Lymph node ratio |  | 1.41 (0.28–7.13) | 0.675 | NA | NA |
Margin status | Negative | 1 | Â | 1 | Â |
Positive | 4.68 (2.08–10.51) | 0.000* | 2.89 (0.97–8.62) | 0.058 | |
Lymphovascular | No | 1 | Â | 1 | Â |
Invasion | Yes | 4.10 (2.23–7.55) | 0.000* | 1.62 (0.70–3.62) | 0.262 |
Tumor grade | G1-G2 | 1 | Â | Â | Â |
G3-G4 | 0.51 (0.25–1.04) | 0.064 | NA | NA | |
Clinical T | T1-T2 | 1 | Â | Â | Â |
T3-T4 | 0.72 (0.35–1.50) | 0.376 | NA | NA | |
Clinical N | N0 | 1 | Â | Â | Â |
N1-N3 | 1.44 (0.80–2.57) | 0.222 | NA | NA | |
Clinical stage | I-II | 1 | Â | Â | Â |
III-IV | 0.86 (0.36–2.03) | 0.729 | NA | NA | |
Mutation count |  | 0.99 (0.98–1.01) | 0.542 | NA | NA |
Fraction genome altered |  | 1.44 (0.29–7.18) | 0.654 | NA | NA |
IRL score |  | 1.78 (1.46–2.17) | 0.000* | 1.57 (1.13–2.20) | 0.007* |