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Table 6 Univariate and multivariate analyses of prognostic factors for OS in advanced-stage diseases

From: Differential roles of the Wip1–p38–p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas

Stages III–IV (n=41)

Univariate

Multivariate

 

HR

95% CI

p-value

HR

95% CI

p-value

High Wip1

4.93

1.70–14.3

0.0033

3.98

1.38–11.5

0.011

Positive p53

0.98

0.40–2.40

0.96

-

-

-

High phospho-p53

0.35

0.10–1.21

0.097

-

-

-

High nuclear phospho-p38

7.86E+07

0–Inf

1.00

-

-

-

High cytoplasmic phospho-p38

0.48

0.20–1.14

0.096

-

-

-

Age ≥60

0.46

0.17–1.25

0.13

-

-

-

Positive peritoneal cytology

1.03

0.30–3.48

0.96

-

-

-

Residual tumor present

2.72

1.45–6.48

0.024

2.39

0.98–5.79

0.055

Endometriosis present

0.82

0.34–1.96

0.66

-

-

-

Lymphadenectmy undone

1.62

0.70–3.75

0.26

-

-

-

Adjuvant chemotherapy performed

NA

NA

NA

-

-

-

Pure histology

1.79

0.42–7.66

0.43

-

-

-

  1. OS overall survival, HR hazard ratio, CI confidence interval, Inf infinity, NA not applicable