Fig. 5

C-myc inhibition counteracted the effects of shRNF180 on NSCLC cell proliferation and glycolysis metabolism. A The proliferation of siRNF180 transfecting cells was inhibited after co-cultured with the C-myc inhibitor 10058-F4. * p < 0.05, ** p < 0.01, and *** p < 0.001. B The inhibitor 10058-F4 inhibited the levels of ECAR in siRNF180 transfecting cells. C Western blot was used to examine the protein levels of C-myc, HK2, and LDHA in cells as indicated above