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Table 3 Pooled ORs and 95% CIs of this meta-analysis for the effect of IL-17A rs2275913 and IL-17F rs763780 polymorphism on colorectal cancer

From: The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis

  Allele model Dominant model Recessive model Homozygous model Heterozygous model
OR (95% CI) P Ph I2(%) OR (95% CI) P Ph I2(%) OR (95% CI) P Ph I2 (%) OR(95% CI) P Ph I2(%) OR(95% CI) P Ph I2(%)
IL-17A rs2275913 (G197A) A vs. G     AA/AG vs. GG     AA vs. GG/AG     AA vs. GG     AG vs. GG    
Total 1.59 (1.34, 1.89)* < 0.001 0.035 53.5 1.75 (1.36, 2.25)* < 0.001 0.018 58.5 1.74 (1.41, 2.15)* < 0.001 0.437 0 2.05 (1.62, 2.60)* < 0.001 0.117 39.4 1.60 (1.23, 2.09)* 0.001 0.020 58.0
Ethnicity
 Asian 1.52 (1.16, 2.01)* 0.003 0.067 63.0 1.62 (1.18, 2.23)* 0.003 0.186 40.6 1.72 (1.26, 2.34)* 0.001 0.131 50.8 2.10 (1.49, 2.96)* < 0.001 0.078 60.8 1.43 (1.14, 1.80)* 0.002 0.516 0
 Caucasian 1.67 (1.30, 2.14)* < 0.001 0.058 56.2 1.88 (1.26, 2.81)* 0.002 0.009 70.3 1.76 (1.32, 2.36)* < 0.001 0.585 0 2.01 (1.46, 2.77)* < 0.001 0.171 37.5 1.76 (1.11, 2.80)* 0.017 0.004 73.9
Genotyping method
 PCR-RFLP 1.47 (1.24, 1.74)* < 0.001 0.156 39.8 1.61 (1.23, 2.11)* 0.001 0.075 52.9 1.68 (1.33, 2.14)* < 0.001 0.219 30.4 1.90 (1.46, 2.47)* < 0.001 0.172 37.4 1.50 (1.08, 2.08)* 0.015 0.028 63.2
 qRT-PCR 2.04 (1.30, 3.20)* 0.002    2.22 (1.27, 3.88)* 0.005    2.26 (0.90, 5.69) 0.084    2.83 (1.10, 7.29)* 0.031    2.03 (1.09, 3.76)* 0.025   
 TaqMan 1.84 (0.90, 3.76) 0.092 0.017 82.5 2.42 (0.68, 8.68) 0.174 0.010 85.0 1.88 (1.10, 3.19)* 0.020 0.400 0 2.71 (1.44, 5.08)* 0.002 0.054 73.1 2.17 (0.69, 6.86) 0.186 0.036 77.1
Source of controls
 PB 1.47 (1.25, 1.72)* < 0.001 0.138 40.1 1.50 (1.23, 1.83)* < 0.001 0.197 31.8 1.74 (1.39, 2.18)* < 0.001 0.465 0 1.96 (1.53, 2.50)* < 0.001 0.260 23.1 1.35 (1.11, 1.65)* 0.003 0.247 25.0
 HB 2.15 (1.41, 3.29)* < 0.001 0.200 39.0 3.15 (1.59, 6.21)* 0.001 0.182 43.9 1.77 (0.98, 3.21) 0.060 0.129 56.5 3.20 (1.52, 6.76)* 0.002 0.053 73.2 2.95 (1.82, 4.79)* < 0.001 0.408 0
IL-17F rs763780 (T7488C) C vs. T     CC/CT vs. TT     CC vs. TT/CT     CC vs. TT     CT vs. TT    
Total 0.94 (0.63, 1.41) 0.776 0.009 67.5 0.96 (0.64, 1.44) 0.845 0.058 56.2 0.71 (0.45, 1.12) 0.141 0.180 36.2 0.78 (0.32, 1.92) 0.588 0.104 51.3 1.01 (0.79, 1.29) 0.929 0.491 0
Ethnicity
 Asian 1.21 (0.73, 2.01) 0.466 0.067 62.9 1.17 (0.72, 1.89) 0.527 0.142 48.8 1.07 (0.53, 2.18) 0.844 0.076 68.2 1.80 (0.20, 15.89) 0.598 0.056 72.7 1.01 (0.77, 1.32) 0.964 0.300 17.0
 Caucasian 0.71 (0.36, 1.36) 0.317 0.043 68.2 0.67 (0.27, 1.63) 0.376 0.055 72.8 0.54 (0.30, 0.98)* 0.042 0.421 0 0.43 (0.21, 0.87)* 0.019 0.694 0 1.03 (0.58, 1.85) 0.910   
Genotyping method
 PCR-RFLP 0.89 (0.54, 1.46) 0.649 0.002 79.3 0.91 (0.58, 1.43) 0.683 0.040 64.0 0.67 (0.41, 1.09) 0.109 0.125 47.8 0.78 (0.32, 1.92) 0.588 0.104 51.3 0.99 (0.76, 1.27) 0.918 0.385 0
 qRT-PCR 1.00 (0.33, 3.03) 0.996        1.00 (0.33, 3.09) 0.996           
 TaqMan 1.34 (0.56, 3.23) 0.507    1.41 (0.55, 3.59) 0.477            1.41 (0.55, 3.59) 0.477   
Source of controls
 PB 0.94 (0.57, 1.55) 0.804 0.004 73.6 0.95 (0.56, 1.63) 0.854 0.029 66.7 0.71 (0.45, 1.12) 0.146 0.099 52.1 0,83 (0.29, 2.40) 0.733 0.046 67.5 1.01 (0.77, 1.32) 0.964 0.300 17.0
 HB 1.01 (0.60, 1.69) 0.976    1.02 (0.58, 1.81) 0.937    0.73 (0.04, 11.78) 0.823    0.73 (0.05,11.94) 0.828    1.03 (0.58, 1.85) 0.910   
  1. N, Number of studies included, OR, Odds ratio, CI, Confidence interval, Ph, p-value for heterogeneity. *OR with statistical significance, P < 0.05 was considered statistically significant