The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis

Li, Gaoming; Ma, Jingfu; Zhang, Ning; Li, Xiaogang; Li, Fangfang; Jiang, Yuxing

doi:10.1186/s12957-022-02586-2

Table 3 Pooled ORs and 95% CIs of this meta-analysis for the effect of IL-17A rs2275913 and IL-17F rs763780 polymorphism on colorectal cancer

From: The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis

	Allele model				Dominant model				Recessive model				Homozygous model				Heterozygous model
	OR (95% CI)	P	P_h	I²(%)	OR (95% CI)	P	P_h	I²(%)	OR (95% CI)	P	P_h	I² (%)	OR(95% CI)	P	P_h	I²(%)	OR(95% CI)	P	P_h	I²(%)
IL-17A rs2275913 (G197A)	A vs. G				AA/AG vs. GG				AA vs. GG/AG				AA vs. GG				AG vs. GG
Total	1.59 (1.34, 1.89)*	< 0.001	0.035	53.5	1.75 (1.36, 2.25)*	< 0.001	0.018	58.5	1.74 (1.41, 2.15)*	< 0.001	0.437	0	2.05 (1.62, 2.60)*	< 0.001	0.117	39.4	1.60 (1.23, 2.09)*	0.001	0.020	58.0
Ethnicity
Asian	1.52 (1.16, 2.01)*	0.003	0.067	63.0	1.62 (1.18, 2.23)*	0.003	0.186	40.6	1.72 (1.26, 2.34)*	0.001	0.131	50.8	2.10 (1.49, 2.96)*	< 0.001	0.078	60.8	1.43 (1.14, 1.80)*	0.002	0.516	0
Caucasian	1.67 (1.30, 2.14)*	< 0.001	0.058	56.2	1.88 (1.26, 2.81)*	0.002	0.009	70.3	1.76 (1.32, 2.36)*	< 0.001	0.585	0	2.01 (1.46, 2.77)*	< 0.001	0.171	37.5	1.76 (1.11, 2.80)*	0.017	0.004	73.9
Genotyping method
PCR-RFLP	1.47 (1.24, 1.74)*	< 0.001	0.156	39.8	1.61 (1.23, 2.11)*	0.001	0.075	52.9	1.68 (1.33, 2.14)*	< 0.001	0.219	30.4	1.90 (1.46, 2.47)*	< 0.001	0.172	37.4	1.50 (1.08, 2.08)*	0.015	0.028	63.2
qRT-PCR	2.04 (1.30, 3.20)*	0.002			2.22 (1.27, 3.88)*	0.005			2.26 (0.90, 5.69)	0.084			2.83 (1.10, 7.29)*	0.031			2.03 (1.09, 3.76)*	0.025
TaqMan	1.84 (0.90, 3.76)	0.092	0.017	82.5	2.42 (0.68, 8.68)	0.174	0.010	85.0	1.88 (1.10, 3.19)*	0.020	0.400	0	2.71 (1.44, 5.08)*	0.002	0.054	73.1	2.17 (0.69, 6.86)	0.186	0.036	77.1
Source of controls
PB	1.47 (1.25, 1.72)*	< 0.001	0.138	40.1	1.50 (1.23, 1.83)*	< 0.001	0.197	31.8	1.74 (1.39, 2.18)*	< 0.001	0.465	0	1.96 (1.53, 2.50)*	< 0.001	0.260	23.1	1.35 (1.11, 1.65)*	0.003	0.247	25.0
HB	2.15 (1.41, 3.29)*	< 0.001	0.200	39.0	3.15 (1.59, 6.21)*	0.001	0.182	43.9	1.77 (0.98, 3.21)	0.060	0.129	56.5	3.20 (1.52, 6.76)*	0.002	0.053	73.2	2.95 (1.82, 4.79)*	< 0.001	0.408	0
IL-17F rs763780 (T7488C)	C vs. T				CC/CT vs. TT				CC vs. TT/CT				CC vs. TT				CT vs. TT
Total	0.94 (0.63, 1.41)	0.776	0.009	67.5	0.96 (0.64, 1.44)	0.845	0.058	56.2	0.71 (0.45, 1.12)	0.141	0.180	36.2	0.78 (0.32, 1.92)	0.588	0.104	51.3	1.01 (0.79, 1.29)	0.929	0.491	0
Ethnicity
Asian	1.21 (0.73, 2.01)	0.466	0.067	62.9	1.17 (0.72, 1.89)	0.527	0.142	48.8	1.07 (0.53, 2.18)	0.844	0.076	68.2	1.80 (0.20, 15.89)	0.598	0.056	72.7	1.01 (0.77, 1.32)	0.964	0.300	17.0
Caucasian	0.71 (0.36, 1.36)	0.317	0.043	68.2	0.67 (0.27, 1.63)	0.376	0.055	72.8	0.54 (0.30, 0.98)*	0.042	0.421	0	0.43 (0.21, 0.87)*	0.019	0.694	0	1.03 (0.58, 1.85)	0.910
Genotyping method
PCR-RFLP	0.89 (0.54, 1.46)	0.649	0.002	79.3	0.91 (0.58, 1.43)	0.683	0.040	64.0	0.67 (0.41, 1.09)	0.109	0.125	47.8	0.78 (0.32, 1.92)	0.588	0.104	51.3	0.99 (0.76, 1.27)	0.918	0.385	0
qRT-PCR	1.00 (0.33, 3.03)	0.996							1.00 (0.33, 3.09)	0.996
TaqMan	1.34 (0.56, 3.23)	0.507			1.41 (0.55, 3.59)	0.477											1.41 (0.55, 3.59)	0.477
Source of controls
PB	0.94 (0.57, 1.55)	0.804	0.004	73.6	0.95 (0.56, 1.63)	0.854	0.029	66.7	0.71 (0.45, 1.12)	0.146	0.099	52.1	0,83 (0.29, 2.40)	0.733	0.046	67.5	1.01 (0.77, 1.32)	0.964	0.300	17.0
HB	1.01 (0.60, 1.69)	0.976			1.02 (0.58, 1.81)	0.937			0.73 (0.04, 11.78)	0.823			0.73 (0.05,11.94)	0.828			1.03 (0.58, 1.85)	0.910

N, Number of studies included, OR, Odds ratio, CI, Confidence interval, P_h, p-value for heterogeneity. *OR with statistical significance, P < 0.05 was considered statistically significant

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