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Table 2 Basic characteristics of included studies for this meta-analysis

From: The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis

Study author Study year Country Ethnicity Cancer type Design Source of controls Genotyping method Matching criteria Cases Controls HWE Quality score
AA AG GG AA AG GG
IL-17A rs2275913
 Omrane et al. 2014 Tunisia Caucasian Colorectal cancer Retrospective study HB PCR-RFLP Not mentioned 3 (2.9%) 51 (50.0%) 48 (47.1%) 6 (4.3%) 38 (27.4%) 95 (68.3%) 0.387 10
 Nemati et al. 2015 Iran Caucasian Colorectal cancer Retrospective study PB PCR-RFLP Age, sex, ethnic, geographic origin 82 (27.0%) 100 (32.9%) 122 (40.1%) 50 (17.4%) 110 (38.2%) 128 (44.4%) 0.002 14
 Samiei et al. 2018 Malaysia Asian Colorectal cancer Retrospective study PB PCR-RFLP Not mentioned 27 (38.6%) 33 (47.1%) 10 (14.3%) 12 (15.0%) 41 (51.2%) 27 (33.8%) 0.577 11
 Al Obeed et al. 2018 Saudi Arabia Caucasian Colorectal cancer Retrospective study PB qRT-PCR Gender, age 17 (14.5%) 40 (34.2%) 60 (51.3%) 7 (7.0%) 23 (23.0%) 70 (70.0%) 0.018 12
 Bedoui et al. 2018 Tunisia Caucasian Colorectal cancer Retrospective study PB TaqMan Ethnic origin 14 (4.8%) 79 (27.1%) 199 (68.1%) 9 (3.5%) 58 (22.2%) 194 (74.3%) 0.084 14
 Feng et al. 2019 China Asian Colorectal cancer Retrospective study PB PCR-RFLP Sex, age 37 (10.5%) 154 (43.9%) 16 0 (45.6%) 31 (7.2%) 169 (39.2%) 231 (53.6%) 0.991 16
 Moundir et al. 2019 Morocco Caucasian Colorectal cancer Retrospective study HB TaqMan Not mentioned 41 (58.6%) 22 (31.4%) 7 (10.0%) 27 (38.6%) 18 (25.7%) 25 (35.7%) < 0.001 6
 Zhang et al. 2020 China Asian Colorectal cancer Retrospective study PB PCR-RFLP Gender, age 41 (19.7%) 110 (52.9%) 57 (27.4%) 45 (14.4%) 149 (47.8%) 118 (37.8%) 0.854 16
IL-17F rs763780
 Omrane et al. 2014 Tunisia Caucasian Colorectal cancer Retrospective study HB PCR-RFLP Not mentioned 1 (0.7%) 38 (27.8%) 98 (71.5%) 1 (1.0%) 27 (27.0%) 72 (72.0%) 0.374 10
 Nemati et al. 2015 Iran Caucasian Colorectal cancer Retrospective study PB PCR-RFLP Age, sex, ethnic, geographic origin 337 (93.6%) 0 (0.0%) 23 (6.4%) 391 (97.3%) 0 (0.0%) 11 (2.7%) < 0.001 14
 Li et al. 2016 China Asian Colorectal cancer Retrospective study PB PCR-HRM Sex, age 0 (0.0%) 13 (26.0%) 37 (74.0%) 0 (0.0%) 10 (20.0%) 40 (80.0%) 0.432 14
 Samiei et al. 2018 Malaysia Asian Colorectal cancer Retrospective study PB PCR-RFLP Not mentioned 5 (7.2%) 25 (35.7%) 40 (57.1%) 1 (1.2%) 23 (28.8%) 56 (70.0%) 0.419 11
 Al Obeed et al. 2018 Saudi Arabia Caucasian Colorectal cancer Retrospective study PB qRT-PCR Gender, age 110 (94.0%) 7 (6.0%) 0 (0.0%) 94 (94.0%) 6 (6.0%) 0 (0.0%) 0.757 15
 Feng et al. 2019 China Asian Colorectal cancer Retrospective study PB PCR-RFLP Sex, age 10 (2.8%) 100 (28.5%) 241 (68.7%) 16 (3.7%) 132 (30.6%) 284 (65.7%) 0.892 16