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Table 1 Characteristics of studies included in the meta-analysis

From: Leiomyosarcoma in the extremities and trunk wall: systematic review and meta-analysis of the oncological outcomes

Study/year N = Age Gender Grade Size in cm Location in relation to fascia Excision margin Adjuvant treatment LR DM Survival data
Hashimoto et al. 1986a [11] 24 Median 55 M: 8
F: 16
1: 6
2: 14
3: 5
≤ 5: 8
> 5: 12
NR: 3
Above: 11
Below: 13
Marginal: 21
Wide: 2
Amputation: 1
CT: 5
RT: 2
11 9 5-year survival
61%
Gustafson et al. 1992 [1] 48 Median 65 M: 26
F: 22
1: 2
2: 4
3: 17
4: 25
≤ 5: 24
> 5: 24
Above: 21
Below: 27
Intralesional: 1
Marginal: 21
Wide: 26
CT: 8
RT: 11
10 20 5-year survival
64%
Miyajima et al. 2002[8] 267 Median 58 M: 125
F: 142
1: 110
2: 115
3: 42
≤ 5: 43
> 5: 143
NR: 83
Above: 105
Below: 162
Resection: 264
Unresectable: 3
0 NR NR AJCC 5-year survival
Stage I 78%
Stage II 49%
Stage III 35%
Stage IV 0%
Farshid et al. 2002 [4] 42 Mean 60 M: 21
F: 21
1 and 2: 20
3: 18
NR: 4
≤ 4: 18
> 4: 20
NR: 4
Above: 15
Below: 27
Intralesional: 4
Marginal: 13
Wide: 21
Indeterminate: 4
CT: 2
RT: 11
3 17 Median survival 35 months
Massi et al. 2004 [7] 42 Median 67.5 M: 20
F: 22
1: 1
2: 12
3: 29
≤ 5: 9
> 5: 33
Above: 1
Below: 41
Intralesional: 5
Marginal: 4
Wide: 33
CT: 9
RT: 21
9 16 5-year survival
32.6%
Svarvar et al. 2006c [12] 225 Median
70
M: 104
F: 121
1: 6
2: 33
3: 75
4: 108
NR: 3
≤ 5: 129
> 5: 91
Above: 137
Below: 88
Intralesional: 21
Marginal: 69
Wide: 129
No surgery: 6
CT: 11
RT: 64
NR 76 5-year survival
64%
Tsiatis et al. 2009 [13] 28 Mean
59
M: 14
F: 14
1: 3
2: 6
3: 19
NR Below: 28 NR RT: 20 NR NR Median survival
35 months
Abraham et al. 2012d [14] 115 Mean
58
M: 48
F: 67
1: 10
2: 25
3: 80
≤ 5: 31
> 5: 84
Above: 20
Below: 95
Intralesional: 17
Marginal: 15
Wide: 57
No surgery: 26
CT: 45
RT: 45
31 70 5-year survival
57%
Gladdy et al. 2013e [6] 353 Median 57 M: 196
F: 157
High: 265
Low: 88
≤ 5: 155
> 5: 194
Above: 96
Below: 257
Intralesional/marginal: 64
Wide: 289
NR 46 109 5-year survival
75%: extremity
81%: trunk
Farid et al. 2013f [15] 46 Median
55
M: 23
F: 23
NR NR NR Intralesional/marginal: 12
Wide: 10
RT: 19 2 12 Mean survival
40.5 months
Gordon et al. 2014 [16] 47 Mean
55.3
M: 24
F: 23
1: 2
2: 5
3: 35
NR: 5
< 10: 16
> 10: 31
Above: 17
Below: 24
Radical: 43
Palliative: 1
No surgery: 3
NR 6 32 NR
Worhunsky et al. 2015 [3] 48 Median
Limbs: 60
Trunk: 55
Limbs
M: 18
F: 8
Trunk
M: 7
F: 15
1/2: 29
3: 19
≤ 5: 29
> 5: 19
Above: 14
Below: 34
Intralesional/marginal: 8
Wide: 40
NR 6 12 NR
Shoushtari et al. 2016[17] 215 Mean
56.4
M: 80
F: 135
1: 7
2: 5
3: 176
NR: 27
< 5: 34
≥ 5: 161
Above: 5
Deep: 196
NR: 14
Intralesional/marginal: 48
Wide: 95
No surgery: 47
NR: 25
NR NR 113 NR
  1. AJCC American Joint Committee on Cancer staging, cm centimeter, CT chemotherapy, DR distant metastasis, female, grading French Federation of Cancer Centers (FNCLCC) grading system, LR local recurrence, male, total sample size, NR not reported, RT radiotherapy
  2. aone case reported anatomical location on the head, which was excluded from the sample size and assumed to be marginal excision. There is insufficient information on adjuvant chemo/radiotherapy, and no recurrence has been reported
  3. blocation of leiomyosarcoma was not specified — assumption made to be trunk and extremities
  4. csix included cases reported anatomical location on the head — information could not be retrieved individually from the pooled summary features
  5. dfifty-four included cases reported anatomical location in the retroperitoneum or others — information could not be retrieved individually from the pooled summary features
  6. eone-hundred and forty-four included cases reported anatomical location in the abdominal or retroperitoneum—information could not be retrieved individually from the pooled summary features
  7. fthirteen included cases reported anatomical location in the gastrointestinal tract, genitourinary, and others—information could not be retrieved individually from the pooled summary features
  8. gone-hundred and sixty-one included cases reported anatomical location in the abdomen and others—information could not be retrieved individually from the pooled summary features