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Table 1 Characteristics of studies included in the meta-analysis

From: Leiomyosarcoma in the extremities and trunk wall: systematic review and meta-analysis of the oncological outcomes

Study/year

N =

Age

Gender

Grade

Size in cm

Location in relation to fascia

Excision margin

Adjuvant treatment

LR

DM

Survival data

Hashimoto et al. 1986a [11]

24

Median 55

M: 8

F: 16

1: 6

2: 14

3: 5

≤ 5: 8

> 5: 12

NR: 3

Above: 11

Below: 13

Marginal: 21

Wide: 2

Amputation: 1

CT: 5

RT: 2

11

9

5-year survival

61%

Gustafson et al. 1992 [1]

48

Median 65

M: 26

F: 22

1: 2

2: 4

3: 17

4: 25

≤ 5: 24

> 5: 24

Above: 21

Below: 27

Intralesional: 1

Marginal: 21

Wide: 26

CT: 8

RT: 11

10

20

5-year survival

64%

Miyajima et al. 2002b [8]

267

Median 58

M: 125

F: 142

1: 110

2: 115

3: 42

≤ 5: 43

> 5: 143

NR: 83

Above: 105

Below: 162

Resection: 264

Unresectable: 3

0

NR

NR

AJCC 5-year survival

Stage I 78%

Stage II 49%

Stage III 35%

Stage IV 0%

Farshid et al. 2002 [4]

42

Mean 60

M: 21

F: 21

1 and 2: 20

3: 18

NR: 4

≤ 4: 18

> 4: 20

NR: 4

Above: 15

Below: 27

Intralesional: 4

Marginal: 13

Wide: 21

Indeterminate: 4

CT: 2

RT: 11

3

17

Median survival 35 months

Massi et al. 2004 [7]

42

Median 67.5

M: 20

F: 22

1: 1

2: 12

3: 29

≤ 5: 9

> 5: 33

Above: 1

Below: 41

Intralesional: 5

Marginal: 4

Wide: 33

CT: 9

RT: 21

9

16

5-year survival

32.6%

Svarvar et al. 2006c [12]

225

Median

70

M: 104

F: 121

1: 6

2: 33

3: 75

4: 108

NR: 3

≤ 5: 129

> 5: 91

Above: 137

Below: 88

Intralesional: 21

Marginal: 69

Wide: 129

No surgery: 6

CT: 11

RT: 64

NR

76

5-year survival

64%

Tsiatis et al. 2009 [13]

28

Mean

59

M: 14

F: 14

1: 3

2: 6

3: 19

NR

Below: 28

NR

RT: 20

NR

NR

Median survival

35 months

Abraham et al. 2012d [14]

115

Mean

58

M: 48

F: 67

1: 10

2: 25

3: 80

≤ 5: 31

> 5: 84

Above: 20

Below: 95

Intralesional: 17

Marginal: 15

Wide: 57

No surgery: 26

CT: 45

RT: 45

31

70

5-year survival

57%

Gladdy et al. 2013e [6]

353

Median 57

M: 196

F: 157

High: 265

Low: 88

≤ 5: 155

> 5: 194

Above: 96

Below: 257

Intralesional/marginal: 64

Wide: 289

NR

46

109

5-year survival

75%: extremity

81%: trunk

Farid et al. 2013f [15]

46

Median

55

M: 23

F: 23

NR

NR

NR

Intralesional/marginal: 12

Wide: 10

RT: 19

2

12

Mean survival

40.5 months

Gordon et al. 2014 [16]

47

Mean

55.3

M: 24

F: 23

1: 2

2: 5

3: 35

NR: 5

< 10: 16

> 10: 31

Above: 17

Below: 24

Radical: 43

Palliative: 1

No surgery: 3

NR

6

32

NR

Worhunsky et al. 2015 [3]

48

Median

Limbs: 60

Trunk: 55

Limbs

M: 18

F: 8

Trunk

M: 7

F: 15

1/2: 29

3: 19

≤ 5: 29

> 5: 19

Above: 14

Below: 34

Intralesional/marginal: 8

Wide: 40

NR

6

12

NR

Shoushtari et al. 2016g [17]

215

Mean

56.4

M: 80

F: 135

1: 7

2: 5

3: 176

NR: 27

< 5: 34

≥ 5: 161

Above: 5

Deep: 196

NR: 14

Intralesional/marginal: 48

Wide: 95

No surgery: 47

NR: 25

NR

NR

113

NR

  1. AJCC American Joint Committee on Cancer staging, cm centimeter, CT chemotherapy, DR distant metastasis, F female, grading French Federation of Cancer Centers (FNCLCC) grading system, LR local recurrence, M male, N total sample size, NR not reported, RT radiotherapy
  2. aone case reported anatomical location on the head, which was excluded from the sample size and assumed to be marginal excision. There is insufficient information on adjuvant chemo/radiotherapy, and no recurrence has been reported
  3. blocation of leiomyosarcoma was not specified — assumption made to be trunk and extremities
  4. csix included cases reported anatomical location on the head — information could not be retrieved individually from the pooled summary features
  5. dfifty-four included cases reported anatomical location in the retroperitoneum or others — information could not be retrieved individually from the pooled summary features
  6. eone-hundred and forty-four included cases reported anatomical location in the abdominal or retroperitoneum—information could not be retrieved individually from the pooled summary features
  7. fthirteen included cases reported anatomical location in the gastrointestinal tract, genitourinary, and others—information could not be retrieved individually from the pooled summary features
  8. gone-hundred and sixty-one included cases reported anatomical location in the abdomen and others—information could not be retrieved individually from the pooled summary features
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World Journal of Surgical Oncology

ISSN: 1477-7819

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