Table 3 Correlation of p53 and OCT1 expression with histological response in the entire cohort

Age (years)

≥ 65

39

29 (74.4%)

10 (25.6%)

1.000

< 65

27

20 (74.1)

7 (25.9)

Sex

Male

51

40 (78.4)

11 (21.6)

0.185

Female

15

9 (60.0)

6 (40.0)

Tumor location

Upper/middle

46

36 (78.3)

10 (21.7)

0.359

Lower/abdominal

20

13 (65.0)

7 (35.0)

Histological type

Well/moderate

54

42 (77.8)

12 (22.2)

0.271

Poor/basaloid

12

7 (58.3)

5 (41.7)

Clinical T factor

cT1/cT2

22

17 (77.3)

5 (22.7)

0.773

cT3/cT4

44

32 (72.7)

12 (27.3)

Clinical N factor

cN0

17

14 (82.4)

3 (17.6)

0.525

cN1–cN4

49

35 (71.4)

14 (28.6)

Clinical stage

II

18

15 (83.3)

3 (16.7)

0.361

III/IVa

48

34 (70.8)

14 (29.2)

Chemotherapy regimen

CF

47

36 (76.6)

11 (23.4)

0.542

DCF

19

13 (68.4)

6 (31.6)

p53 expression

Wild type

27

16 (59.3)

11(40.7)

0.026*

Mutant type

39

33 (84.6)

6 (15.4)

OCT1 expression

High

30

19 (71.4)

11 (28.6)

0.091

Low

36

30 (83.3)

6 (16.7)

p53/OCT1 expression

Both p53^WT-ex and OCT1^High

11

3 (27.3)

8 (72.7)

< 0.001*

Either p53^MT-ex or OCT1^Low

55

46 (83.6)

9 (16.4)