Expression status of p53 and organic cation transporter 1 is correlated with poor response to preoperative chemotherapy in esophageal squamous cell carcinoma

Table 2 Correlation of p53 and OCT1 expression with clinicopathological parameters

Parameter		n	p53^WT-ex	p53^MT-ex	P-value	OCT1^High	OCT1^Low	P-value
Age (years)	≥ 65	39	15 (38.5%)	24 (61.5%)	0.799	17 (43.6%)	22 (56.4%)	0.803
Age (years)	< 65	27	12 (44.4)	15 (55.6)		13 (48.1)	14 (51.9)
Sex	Male	51	20 (39.2)	31 (60.8)	0.766	24 (47.1)	27 (52.9)	0.770
Sex	Female	15	7 (46.7)	8 (53.3)		6 (40.0)	9 (60.0)
Tumor location	Upper/middle	46	18 (39.1)	28 (60.9)	0.786	19 (41.3)	27 (58.7)	0.421
Tumor location	Lower/abdominal	20	9 (45.0)	11 (55.0)		11 (55.0)	9 (45.0)
Histological type	Well/moderate	54	21 (38.9)	33 (61.1)	0.528	25 (46.3)	29 (53.7)	1.000
Histological type	Poor/basaloid	12	6 (50.0)	6 (50.0)		5 (41.7)	7 (58.3)
Clinical T factor	cT1/cT2	22	7 (31.8)	15 (68.2)	0.426	12 (54.5)	10 (46.5)	0.310
Clinical T factor	cT3/cT4	44	20 (45.5)	24 (54.5)		18 (40.9)	26 (59.1)
Clinical N factor	cN0	17	7 (41.2)	10 (58.8)	1.000	10 (58.8)	7 (41.2)	0.261
Clinical N factor	cN1–cN4	49	20 (40.8)	29 (59.2)		20 (40.8)	29 (59.2)
Clinical stage	II	18	8 (44.4)	10 (55.6)	0.783	9 (50.0)	9 (50.0)	0.783
Clinical stage	III/IVa	48	19 (39.6)	29 (60.4)		21 (43.8)	27 (56.2)
Chemotherapy regimen	CF	47	20 (42.6)	27 (57.4)	0.785	23 (48.9)	24 (51.1)	0.423
Chemotherapy regimen	DCF	19	7 (36.8)	12 (63.2)		7 (36.8)	12 (64.2)

CF cisplatin/5-fluorouracil, DCF docetaxel/cisplatin/5-fluorouracil, OCT1 organic cation transporter 1

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