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Table 4 The relationship between the expression of STEAP2 and clinicopathological features of NSCLC patients

From: Expression and prognostic analyses of the significance of STEAP1 and STEAP2 in lung cancer

Pathological features

N

STEAP2

χ2

P

High expression

Low expression

n (%)

n (%)

Age

  

0.198

0.656

 ≤60

130

23 (17.7)

107 (82.3)

  

 >60

128

20 (15.6)

108 (84.4)

  

Sex

   

0.030

0.864

 Male

159

27 (17.0)

132 (83.0)

  

 Female

99

16 (16.2)

83 (83.8)

  

TNM clinical stages

   

19.379

0.000

 I and II stages

108

31 (28.7)

77 (71.3)

  

 III and IV stages

150

12 (8.0)

138 (92.0)

  

Histological type

   

0.230※

0.891※

 Squamous carcinoma

121

20 (16.5)

101 (83.5)

9.408#

0.009#

  I grade

32

13 (40.6)

19 (59.4)

  

  II grade

48

13 (27.1)

35 (72.9)

  

  III grade

41

4 (9.8)

37 (90.2)

  

 Adenocarcinoma

112

18 (16.1)

94 (83.9)

14.298*

0.006*

  Lepidic-predominant

25

12 (48.0)

13 (52.0)

  

  Acinar-predominant

21

9 (42.9)

12 (57.1)

  

  Papillary-predominant

19

6 (31.6)

13 (68.4)

  

  Solid-predominant

24

3 (12.5)

21 (87.5)

  

  Micropapillary-predominant

23

2 (8.7)

21(91.3)

  

 Adenosquamous carcinoma

25

5 (20.0)

20 (80.0)

  

Lymphatic metastasis

  

35.352

0.000

 N0

95

33 (34.7)

62 (65.3)

  

 N+

163

10 (6.1)

153 (93.9)

  
  1. ※There was no statistical significance in the high expression rate of STEAP2 in different pathological types of NSCLC, such as squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma (P > 0.05). #There was statistical significance in the high expression rate of STEAP2 in different histological grades of squamous cell carcinoma, when the histological grade increased, the high expression rate of STEAP2 decreased (P < 0.05). *There was statistical significance in the high expression rate of STEAP2 in different pathological subtypes of adenocarcinoma; the high expression rate of STEAP2 in well-differentiated lepidic adenocarcinoma was significantly higher than that in poorly differentiated solid and micropapillary adenocarcinoma (P < 0.05)