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Table 3 The relationship between the expression of STEAP1 and clinicopathological features of NSCLC patients

From: Expression and prognostic analyses of the significance of STEAP1 and STEAP2 in lung cancer

Pathological features

N

STEAP1

χ2

P

High expression

Low expression

  

n (%)

n (%)

  

Age

 

2.721

0.099

 ≤60

130

116 (89.2)

14 (10.8)

  

 >60

128

105 (82.0)

23 (18.0)

  

Sex

 

0.433

0.510

 Male

159

138 (86.8)

21 (13.2)

  

 Female

99

83 (83.8)

16 (16.2)

  

TNM clinical stages

 

23.668

0.000

 I and II stages

108

79 (73.1)

29 (26.9)

  

 III and IV stages

150

142 (94.7)

8 (5.3)

  

Histological type

 

0.520※

0.974※

 Squamous carcinoma

121

103 (85.1)

18 (14.9)

11.140#

0.004#

  I grade

32

18 (56.3)

14 (43.7)

  

  II grade

48

36 (75.0)

12 (25.0)

  

  III grade

41

37 (90.2)

4 (9.8)

  

 Adenocarcinoma

112

96 (85.7)

16 (14.3)

13.684*

0.008*

  Lepidic-predominant

25

13 (52.0)

12 (48.0)

  

  Acinar-predominant

21

13 (61.9)

8 (38.1)

  

  Papillary-predominant

19

12 (63.2)

7 (36.8)

  

  Solid-predominant

24

21 (87.5)

3 (12.5)

  

  Micropapillary-predominant

23

21 (91.3)

2 (8.7)

  

 Adenosquamous carcinoma

25

21 (84.0)

4 (16.0)

  

Lymphatic metastasis

 

32.066

0.000

 N0

95

66 (69.5)

29 (30.5)

  

 N+

163

155 (95.1)

8 (4.9)

  
  1. ※There was no statistical significance in the high expression rate of STEAP1 in different pathological types of NSCLC, such as squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma (P > 0.05). #There was statistical significance in the high expression rate of STEAP1 in different histological grades of squamous cell carcinoma, when the histological grade increased, the high expression rate of STEAP1 increased (P < 0.05). *There was statistical significance in the high expression rate of STEAP1 in different pathological subtypes of adenocarcinoma; the high expression rate of STEAP1 in well-differentiated lepidic adenocarcinoma was significantly lower than that in poorly differentiated solid and micropapillary adenocarcinoma (P < 0.05)