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Table 2 Univariate and multivariate prognostic analysis for disease-specific survival among all patients

From: Intended preoperative trans-arterial embolization for large hepatocellular carcinoma: a retrospective cohort study

Variable Indicator Univariate Multivariate
p value HR 95% CI (range) p value
Age ≥70 (vs <70) 0.123     
Sex Female (vs male) 0.161     
HBV infection Present (vs absent) 0.214     
HCV infection Present (vs absent) 0.255     
Cirrhosis Present (vs Absent) 0.054 1.088 0.6123 1.935 0.773
Child-Pugh B (vs A) <0.001 1.019 0.3546 2.928 0.972
AFP (ng/ml) ≥10 (vs <10) 0.005 0.929 0.4952 1.743 0.819
AFP-L3 (%) ≥10 (vs <10) 0.028 1.595 0.8469 3.003 0.148
PIVKA-II (mAU/ml) ≥40 (vs <40) <0.001 1.645 0.9274 2.919 0.089
Tumor number Multiple (vs aingle) 0.022 1.206 0.7079 2.055 0.491
Tumor size (mm) ≥50 (vs <50) 0.006 0.7701 0.3534 1.678 0.511
LN metastasis Present (vs absent) <0.001 3.345 0.7132 15.69 0.126
Vascular invasions Present (vs absent) <0.001 2.125 1.234 3.659 0.007
Differentiation Por/undif (vs well/mod) 0.003 1.358 0.7725 2.388 0.288
Residual tumor R1/2 (vs R0) <0.001 5.986 2.366 15.14 <0.001
Postoperative complications ≥CD2 (vs ≤CD1) 0.022 1.417 0.816 2.462 0.216
Blood transfusion Present (vs absent) <0.001 2.502 1.355 4.623 0.003
  1. HR hazard ratio, CI confidence interval, HBV hepatitis B virus, HCV hepatitis C virus, AFP alpha-fetoprotein, AFP-L3 L3 fraction of alpha-fetoprotein, PIVKA-II protein-induced vitamin K absence or antagonist-II, LN lymph node, Por poorly differentiated, Undif undifferentiated, Well well-differentiated, Mod moderately differentiated, CD Clavien-Dindo classification