|
Variable
|
Indicator
|
Univariate
|
Multivariate
|
|---|
|
p value
|
HR
|
95% CI (range)
|
p value
|
|---|
|
Age
|
≥70 (vs <70)
|
0.123
| | | | |
|
Sex
|
Female (vs male)
|
0.161
| | | | |
|
HBV infection
|
Present (vs absent)
|
0.214
| | | | |
|
HCV infection
|
Present (vs absent)
|
0.255
| | | | |
|
Cirrhosis
|
Present (vs Absent)
|
0.054
|
1.088
|
0.6123
|
1.935
|
0.773
|
|
Child-Pugh
|
B (vs A)
|
<0.001
|
1.019
|
0.3546
|
2.928
|
0.972
|
|
AFP (ng/ml)
|
≥10 (vs <10)
|
0.005
|
0.929
|
0.4952
|
1.743
|
0.819
|
|
AFP-L3 (%)
|
≥10 (vs <10)
|
0.028
|
1.595
|
0.8469
|
3.003
|
0.148
|
|
PIVKA-II (mAU/ml)
|
≥40 (vs <40)
|
<0.001
|
1.645
|
0.9274
|
2.919
|
0.089
|
|
Tumor number
|
Multiple (vs aingle)
|
0.022
|
1.206
|
0.7079
|
2.055
|
0.491
|
|
Tumor size (mm)
|
≥50 (vs <50)
|
0.006
|
0.7701
|
0.3534
|
1.678
|
0.511
|
|
LN metastasis
|
Present (vs absent)
|
<0.001
|
3.345
|
0.7132
|
15.69
|
0.126
|
|
Vascular invasions
|
Present (vs absent)
|
<0.001
|
2.125
|
1.234
|
3.659
|
0.007
|
|
Differentiation
|
Por/undif (vs well/mod)
|
0.003
|
1.358
|
0.7725
|
2.388
|
0.288
|
|
Residual tumor
|
R1/2 (vs R0)
|
<0.001
|
5.986
|
2.366
|
15.14
|
<0.001
|
|
Postoperative complications
|
≥CD2 (vs ≤CD1)
|
0.022
|
1.417
|
0.816
|
2.462
|
0.216
|
|
Blood transfusion
|
Present (vs absent)
|
<0.001
|
2.502
|
1.355
|
4.623
|
0.003
|
- HR hazard ratio, CI confidence interval, HBV hepatitis B virus, HCV hepatitis C virus, AFP alpha-fetoprotein, AFP-L3 L3 fraction of alpha-fetoprotein, PIVKA-II protein-induced vitamin K absence or antagonist-II, LN lymph node, Por poorly differentiated, Undif undifferentiated, Well well-differentiated, Mod moderately differentiated, CD Clavien-Dindo classification
