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Table 2 GSEA analysis of B3GNT6 mRNA expression in GSE39582

From: Downregulation of B3GNT6 is a predictor of poor outcomes in patients with colorectal cancer

Geneset name NES NOM p-val FDR q-val
BIOCARTA pathway
 Upregulated
  BIOCARTA_RAB_PATHWAY 1.6703635 0.026 0.33836955
  BIOCARTA_CERAMIDE_PATHWAY 1.6385397 0.03807615 0.34184185
 Downregulated
  BIOCARTA_PROTEASOME_PATHWAY 1.865893 0.011235955 0.15191999
  KEGG pathway
 Upregulated
  KEGG_OLFACTORY_TRANSDUCTION 2.0274692 0 0.027611418
  KEGG_TASTE_TRANSDUCTION 1.7740936 0 0.19784024
  KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES 1.770417 0.001926782 0.13674085
  KEGG_O_GLYCAN_BIOSYNTHESIS 1.7251008 0.007736944 0.16378903
  KEGG_GNRH_SIGNALING_PATHWAY 1.7178557 0 0.14160849
  KEGG_ALZHEIMERS_DISEASE 1.6913323 0.026923077 0.15125382
  KEGG_NITROGEN_METABOLISM 1.6708751 0.001992032 0.13392551
  KEGG_LONG_TERM_POTENTIATION 1.64782 0.024528302 0.14832915
  KEGG_HUNTINGTONS_DISEASE 1.638019 0.04660194 0.14545798
  KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 1.63744 0.018072288 0.1325422
  KEGG_BUTANOATE_METABOLISM 1.6251645 0.01778656 0.13560429
  KEGG_DRUG_METABOLISM_OTHER_ENZYMES 1.6193944 0.01178782 0.13172121
  KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 1.5756354 0.025742574 0.17885368
  KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 1.5706768 0.027613413 0.17375107
  KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 1.5477382 0.046092186 0.19446045
  KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 1.5473746 0.023391813 0.18385722
  KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 1.5310374 0.015873017 0.1866673
  KEGG_RETINOL_METABOLISM 1.526893 0.02970297 0.18341947
  KEGG_GLYCOLYSIS_GLUCONEOGENESIS 1.5237751 0.038 0.17888556
  KEGG_VIBRIO_CHOLERAE_INFECTION 1.5188705 0.020876827 0.17640822
  KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 1.4940959 0.048543688 0.20143263
  KEGG_STARCH_AND_SUCROSE_METABOLISM 1.4879901 0.037848607 0.20171466
  KEGG_ASCORBATE_AND_ALDARATE_METABOLISM 1.4647686 0.03976143 0.21592942
 Downregulated
  KEGG_BASAL_TRANSCRIPTION_FACTORS −1.7745181 0.009920635 0.3991878
  KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 1.773844 0.013861386 0.20233367
  KEGG_RNA_DEGRADATION −1.6950728 0.028688524 0.21618877
  KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE −1.5696611 0.020715632 0.3765442
  KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE −1.5518181 0.04183267 0.3753312
  1. NES normalized enrichment score, that is, the enrichment score for the gene set after it has been normalized across analyzed gene sets. FDR q-val false discovery rate, that is, the estimated probability that the normalized enrichment score represents a false positive finding. NOM p-val normalized p value, that is, the statistical significance of the enrichment score. The nominal p value is not adjusted for gene set size or multiple hypothesis testing; therefore, it is of limited use in comparing gene sets