Table 4 Results of the Cox regression analyses and multivariable Cox regression analyses on variables with impact on overall survival. In-house mortality cases were excluded

 Chemotherapy on primary tumor (Ref. yes)

< 0.001

0.722 (0.604–0.863)

0.002

0.732 (0.603–0.888)

 Development of CRLM (Ref. metachronous)

0.101

1.151 (0.973–1.361)

0.835

Not applicable

 Age at liver resection > 70 years

0.009

1.290 (1.066–1.562)

0.005

1.357 (1.095–1.683)

 Number of CRLM

< 0.001

1.115 (1.076–1.156)

0.001

1.071 (1.028–1.115)

 Size of CRLM > 50 mm

< 0.001

1.416 (1.200–1.671)

0.018

1.256 (1.040–1.517)

 Preoperative hemoglobin

0.017

0.939 (0.891–0.989)

0.683

Not applicable

 Preoperative platelets

0.148

1.001 (1.000–1.002)

0.339

 Preoperative quick

0.127

0.996 (0.990–1.001)

0.826

 Preoperative eGFR < 90 ml/min (Ref. normal values)

0.036

1.196 (1.012–1.413)

0.113

 Extent of liver resection (Ref. minor)

0.038

1.190 (1.009–1.404)

0.830

 Operative duration > 120 min (Ref. no)

< 0.001

1.460 (1.192–1.788)

0.006

1.385 (1.096–1.749)

 Use of Pringle’s maneuver (Ref. not used)

0.380

1.038 (0.907–1.293)

0.643

Not applicable

 Weight of liver specimen > 450 g

0.062

1.170 (0.992–1.380)

0.295

 Distance to resection margin in mm

0.005

0.984 (0.973–0.995)

0.041

0.988 (0.977–1.000)

 R1-status (Ref. R0)

0.466

1.129 (0.815–1.564)

0.425

Not applicable

 R2-status (Ref. R0)

0.261

1.658 (0.687–4.002)

0.440

 Overall transfusion of > 2 units PRBC (Ref. no)

< 0.001

1.468 (1.243–1.734)

0.039

1.223 (1.010–1.482)

 Postoperative complications graded Dindo-Clavien > 3 (Ref. no)

0.063

1.259 (0.988–1.605)

0.285

Not applicable

 eGFR at dismission < 90% of preoperative eGFR (Ref. < 90%)

0.494

1.096 (0.843–1.423)

0.915

 Stay on intensive care unit (days)

< 0.001

1.029 (1.016–1.042)

0.122

 Overall hospital stay > 14 days (Ref.no)

< 0.001

1.382 (1.162–1.643)

0.190