Table 2 Univariate and multivariate Cox regression analysis of clinical factors and prognostic risk signature in the training cohort, the testing cohort and the entire cohort

Age: ≤ 65 vs. > 65

1.03

1.23e-03

1.04

1.10e-04

1.03

5.91e-03

1.04

9.28e-04

1.03

1.24e-05

1.04

2.98e-07

Gender: Female vs. Male

0.95

0.82

1.20

0.43

0.91

0.70

0.78

0.36

0.94

0.70

1.03

0.87

Grade: G1–2 vs. G3–4

2.05

7.1e-07

1.27

0.16

2.72

3.51e-09

1.67

7.49e-03

2.30

2.24e-14

1.31

3.09e-02

AJCC stage: I/II vs. III/IV

1.95

3.4e-13

1.75

0.08

1.91

3.42e-09

2.17

8.13e-03

1.93

9.60e-21

1.98

1.40e-03

T stage: T1–2 vs. T3–4

2.14

2.92e-11

1.00

0.99

1.80

1.35e-05

0.58

4.80e-02

1.99

3.80e-15

0.73

0.11

M stage: M0 vs. M1

4.07

1.76e-10

0.96

0.94

5.05

8.65e-11

1.38

0.50

4.39

2.68e-19

1.13

0.75

Risk score: Low vs. High

1.42

6.65e-12

1.46

5.13e-11

1.78

6.33e-08

1.68

4.14e-04

2.08

8.98e-22

2.04

6.91e-14