Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95%CI) | P | HR (95%CI) | P | |
Gender (male vs female) | 1.01 (0.66–1.52) | 0.975 | 0.97 (0.60–1.57) | 0.905 |
Age (years, <60 vs ≥60) | 1.29 (0.86–1.94) | 0.213 | 1.56 (0.97–2.52) | 0.069 |
Adjuvant therapy | ||||
 No | Ref. | - | Ref. | - |
 Chemotherapy | 1.49 (0.95–2.32) | 0.082 | 1.12 (0.63–1.98) | 0.702 |
 Other | 1.70 (0.60–4.86) | 0.320 | 1.12 (0.35–3.57) | 0.845 |
BMI | ||||
 ≥24 | Ref. | - | Ref. | - |
 <18.5 | 0.90 (0.35–2.33) | 0.828 | 1.59 (0.58–4.38) | 0.368 |
 18.5–23.9 | 1.09 (0.69–1.70) | 0.719 | 1.23 (0.74–2.02) | 0.426 |
Smoking (yes vs no) | 1.11 (0.60–2.05) | 0.734 | 1.09 (0.56–2.11) | 0.809 |
Drinking (yes vs no) | 0.96 (0.61–1.50) | 0.849 | 1.16 (0.69–1.93) | 0.576 |
Comorbidity (yes vs no) | 1.07 (0.71–1.60) | 0.744 | 1.22 (0.78–1.93) | 0.381 |
Family history of cancer (yes vs no) | 0.80 (0.49–1.31) | 0.380 | 0.79 (0.47–1.34) | 0.377 |
Tumor stage | ||||
 I | Ref. | - | Ref. | - |
 II | 1.35 (0.59–3.10) | 0.473 | 0.80 (0.32–2.01) | 0.641 |
 III | 2.60 (1.21–5.58) | 0.014 | 1.04 (0.35–3.13) | 0.942 |
 IV | 15.70 (7.09–34.56) | <0.001 | 4.91 (1.61–15.03) | 0.005 |
Specimen type | ||||
 Raised type | Ref. | - | Ref. | - |
 Ulcer type | 1.50 (0.94–2.41) | 0.090 | 1.14 (0.68–1.90) | 0.619 |
 Other | 3.94 (2.14–7.27) | <0.001 | 1.82 (0.90–3.69) | 0.098 |
Tumor differentiation | ||||
 Well | Ref. | - | Ref. | - |
 Moderate | 1.21 (0.38–3.86) | 0.747 | 0.53 (0.15–1.80) | 0.306 |
 Poor | 4.96 (1.31–16.81) | 0.018 | 1.39 (0.33–5.74) | 0.653 |
 Undifferentiated | 1.96 (0.50–7.65) | 0.333 | 1.09 (0.25–4.77) | 0.911 |
Histological classification | ||||
 Adenocarcinoma | Ref. | - | Ref. | - |
 Mucinous carcinoma and other | 1.22 (0.68–2.19) | 0.512 | 0.48 (0.23–1.03) | 0.059 |
Tumor site | ||||
 Colon | Ref. | - | Ref. | - |
 Rectum | 0.70 (0.46–1.07) | 0.103 | 1.07 (0.66–1.73) | 0.794 |
 Other | 0.85 (0.31–2.34) | 0.753 | 1.19 (0.41–3.47) | 0.748 |
Lymph node metastasis (yes vs no) | 2.63 (1.74–3.98) | <0.001 | 1.93 (0.94–3.95) | 0.073 |
Tumor size (≥3 vs <3) | 0.69 (0.42–1.13) | 0.144 | 0.73 (0.42–1.27) | 0.261 |
AFP (<20 vs ≥20) | 0.58 (0.37–0.90) | 0.016 | 0.53 (0.33–0.86) | 0.010 |
CEA (<5 vs ≥5) | 0.41 (0.27–0.63) | <0.001 | 0.54 (0.33–0.89) | 0.015 |
CA199 (<37 vs ≥37) | 0.40 (0.26–0.62) | <0.001 | 0.93 (0.55–1.58) | 0.786 |
NSAP (≤1.05 vs >1.05) | 0.39 (0.25–0.61) | <0.001 | 0.53 (0.32–0.87) | 0.013 |