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Table 2 Univariate and multivariate analysis for disease-free survival

From: A novel inflammation-related prognostic biomarker for predicting the disease-free survival of patients with colorectal cancer

Variables

Univariate analysis

Multivariate analysis

HR (95%CI)

P

HR (95%CI)

P

Gender (male vs female)

1.01 (0.66–1.52)

0.975

0.97 (0.60–1.57)

0.905

Age (years, <60 vs ≥60)

1.29 (0.86–1.94)

0.213

1.56 (0.97–2.52)

0.069

Adjuvant therapy

 No

Ref.

-

Ref.

-

 Chemotherapy

1.49 (0.95–2.32)

0.082

1.12 (0.63–1.98)

0.702

 Other

1.70 (0.60–4.86)

0.320

1.12 (0.35–3.57)

0.845

BMI

 ≥24

Ref.

-

Ref.

-

 <18.5

0.90 (0.35–2.33)

0.828

1.59 (0.58–4.38)

0.368

 18.5–23.9

1.09 (0.69–1.70)

0.719

1.23 (0.74–2.02)

0.426

Smoking (yes vs no)

1.11 (0.60–2.05)

0.734

1.09 (0.56–2.11)

0.809

Drinking (yes vs no)

0.96 (0.61–1.50)

0.849

1.16 (0.69–1.93)

0.576

Comorbidity (yes vs no)

1.07 (0.71–1.60)

0.744

1.22 (0.78–1.93)

0.381

Family history of cancer (yes vs no)

0.80 (0.49–1.31)

0.380

0.79 (0.47–1.34)

0.377

Tumor stage

 I

Ref.

-

Ref.

-

 II

1.35 (0.59–3.10)

0.473

0.80 (0.32–2.01)

0.641

 III

2.60 (1.21–5.58)

0.014

1.04 (0.35–3.13)

0.942

 IV

15.70 (7.09–34.56)

<0.001

4.91 (1.61–15.03)

0.005

Specimen type

 Raised type

Ref.

-

Ref.

-

 Ulcer type

1.50 (0.94–2.41)

0.090

1.14 (0.68–1.90)

0.619

 Other

3.94 (2.14–7.27)

<0.001

1.82 (0.90–3.69)

0.098

Tumor differentiation

 Well

Ref.

-

Ref.

-

 Moderate

1.21 (0.38–3.86)

0.747

0.53 (0.15–1.80)

0.306

 Poor

4.96 (1.31–16.81)

0.018

1.39 (0.33–5.74)

0.653

 Undifferentiated

1.96 (0.50–7.65)

0.333

1.09 (0.25–4.77)

0.911

Histological classification

 Adenocarcinoma

Ref.

-

Ref.

-

 Mucinous carcinoma and other

1.22 (0.68–2.19)

0.512

0.48 (0.23–1.03)

0.059

Tumor site

 Colon

Ref.

-

Ref.

-

 Rectum

0.70 (0.46–1.07)

0.103

1.07 (0.66–1.73)

0.794

 Other

0.85 (0.31–2.34)

0.753

1.19 (0.41–3.47)

0.748

Lymph node metastasis (yes vs no)

2.63 (1.74–3.98)

<0.001

1.93 (0.94–3.95)

0.073

Tumor size (≥3 vs <3)

0.69 (0.42–1.13)

0.144

0.73 (0.42–1.27)

0.261

AFP (<20 vs ≥20)

0.58 (0.37–0.90)

0.016

0.53 (0.33–0.86)

0.010

CEA (<5 vs ≥5)

0.41 (0.27–0.63)

<0.001

0.54 (0.33–0.89)

0.015

CA199 (<37 vs ≥37)

0.40 (0.26–0.62)

<0.001

0.93 (0.55–1.58)

0.786

NSAP (≤1.05 vs >1.05)

0.39 (0.25–0.61)

<0.001

0.53 (0.32–0.87)

0.013