Fig. 7

The correlation between the expression levels of hub genes and the infiltration of six immune cells and the TMB score in LUAD patients. A CDCA5 was positively correlated with B cell and CD4+ T cell; CDCA8 and KNTC1 were positively correlated with neutrophil; the rest of hub genes were negatively correlated with most immune cells. B Oncoplot displaying the somatic landscape of the LUAD cohort. The mutation frequencies of AURKB, CDC20, CENPF, and KNTC1 in LUAD patients were 1%, 1%, 6%, and 3%, respectively. In addition, missense mutation is the main mutation type. C–F Correlation analysis between hub gene expression and TMB score. AURKB, CDC20, CENPF, and KNTC1 were all positively correlated with the TMB score, and the Spearman correlation coefficients were 0.46, 0.47, 0.40, and 0.39, respectively