Table 3 Univariable logistic regression analysis and multivariable logistic regression analysis of VER in development cohort

Gender(male)

2.83(0.75–10.69)

0.124

Age (>= 65 years)

0.5(0.17–1.5)

0.219

1(0.49–2.05)

0.993

Tumor number (multiple)

2.65(1.19–5.89)

0.017

1.06(0.36–3.14)

0.920

Tumor size (>= 5 cm)

1.94(0.95–3.94)

0.069

Tumor capsule (present)

0.76(0.37–1.56)

0.449

Microvascular invasion (present)

3.09(1.45–6.57)

0.003

3.73(1.43–9.71)

0.007

Macrovascular invasion (present)

5.44(1.98–14.96)

0.001

5.75(1.73–19.04)

0.004

Satellite nodules (present)

3.54(1.68–7.46)

< 0.001

2.5(0.98–6.4)

0.056

Edmondson-Steiner classification(III/IV)

0.66(0.26–1.68)

0.387

RBC(>= 4 × 10^12/L)

0.8(0.22–2.88)

0.733

1.97(0.42–9.2)

0.387

PLT(< 300 × 10^9/L)

0.8(0.25–2.53)

0.704

Neutrophil count(>= 5 × 10^9/L)

0.57(0.26–1.29)

0.181

Lymphocyte count(>= 1.5 × 10^9/L)

0.97(0.43–2.18)

0.937

NLR(>= 1.6)

0.57(0.23–1.43)

0.230

AST(>= 40 U/L)

1(0.5–2.01)

0.991

PT(>= 13 s)

1.25(0.4–3.95)

0.704

TB(>= 17.1 umol/L)

0.83(0.39–1.75)

0.618

ALB(< 40 g/L)

1.03(0.47–2.23)

0.949

GGT(>= 75 U/L)

1.76(0.87–3.55)

0.116

ALP(>= 78 U/L)

4.07(1.79–9.23)

< 0.001

2.03(0.77–5.33)

0.152

AFP(>= 20 ng/mL)

2.77(1.28–5.97)

0.009

1.97(0.78–4.96)

0.152

CEA(>= 5 ng/mL)

0.84(0.29–2.46)

0.747

CA19-9(>= 25 U/mL)

3.66(1.73–7.73)

< 0.001

2.48(1–6.13)

0.049

DCP(>= 200 mAU/mL)

2.62(1.24–5.57)

0.012

1.43(0.57–3.58)

0.440

Intraoperative blood loss(>= 200 mL)

0.96(0.47–1.94)

0.906

Intraoperative blood transfusion (yes)

0.82(0.38–1.79)

0.622