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Table 3 Univariable logistic regression analysis and multivariable logistic regression analysis of VER in development cohort

From: Development and validation of nomogram to predict very early recurrence of combined hepatocellular-cholangiocarcinoma after hepatic resection: a multi-institutional study

Variables Univariable logistic regression analysis Multivariable logistic regression analysis
OR (95% CI) P value OR (95% CI) P value
Gender(male) 2.83(0.75–10.69) 0.124   
Age (>= 65 years) 0.5(0.17–1.5) 0.219   
Hepatitis
 HBV vs NBNC 1.62(0.53–4.98) 0.396   
 HCV vs NBNC 2.2(0.11–42.74) 0.602   
NAFLD (yes) 2.21(0.36–13.67) 0.395   
Cirrhosis (yes) 1(0.49–2.05) 0.993   
Resection type (major resection) 1.82(0.85–3.91) 0.122   
Lymph node dissection (yes) 1.72(0.65–4.56) 0.278   
Tumor number (multiple) 2.65(1.19–5.89) 0.017 1.06(0.36–3.14) 0.920
Tumor size (>= 5 cm) 1.94(0.95–3.94) 0.069   
Tumor capsule (present) 0.76(0.37–1.56) 0.449   
Microvascular invasion (present) 3.09(1.45–6.57) 0.003 3.73(1.43–9.71) 0.007
Macrovascular invasion (present) 5.44(1.98–14.96) 0.001 5.75(1.73–19.04) 0.004
Satellite nodules (present) 3.54(1.68–7.46) < 0.001 2.5(0.98–6.4) 0.056
Edmondson-Steiner classification(III/IV) 0.66(0.26–1.68) 0.387   
RBC(>= 4 × 10^12/L) 0.8(0.22–2.88) 0.733   
Hb(< 120 × g/L) 1.97(0.42–9.2) 0.387   
PLT(< 300 × 10^9/L) 0.8(0.25–2.53) 0.704   
Neutrophil count(>= 5 × 10^9/L) 0.57(0.26–1.29) 0.181   
Lymphocyte count(>= 1.5 × 10^9/L) 0.97(0.43–2.18) 0.937   
NLR(>= 1.6) 0.57(0.23–1.43) 0.230   
AST(>= 40 U/L) 1(0.5–2.01) 0.991   
PT(>= 13 s) 1.25(0.4–3.95) 0.704   
TB(>= 17.1 umol/L) 0.83(0.39–1.75) 0.618   
ALB(< 40 g/L) 1.03(0.47–2.23) 0.949   
GGT(>= 75 U/L) 1.76(0.87–3.55) 0.116   
ALP(>= 78 U/L) 4.07(1.79–9.23) < 0.001 2.03(0.77–5.33) 0.152
AFP(>= 20 ng/mL) 2.77(1.28–5.97) 0.009 1.97(0.78–4.96) 0.152
CEA(>= 5 ng/mL) 0.84(0.29–2.46) 0.747   
CA19-9(>= 25 U/mL) 3.66(1.73–7.73) < 0.001 2.48(1–6.13) 0.049
DCP(>= 200 mAU/mL) 2.62(1.24–5.57) 0.012 1.43(0.57–3.58) 0.440
Intraoperative blood loss(>= 200 mL) 0.96(0.47–1.94) 0.906   
Intraoperative blood transfusion (yes) 0.82(0.38–1.79) 0.622   
  1. HBV hepatitis B virus, HCV hepatitis C virus, NAFLD non-alcoholic fatty liver disease, RBC red blood cell, Hb hemoglobin, PLT platelet count, NLR neutrophils/lymphocytes ratio, AST aspartate aminotransferase, PT prothrombin time, TB total bilirubin, ALB albumin, GGT gamma-glutamyl transpeptidase, ALP alkaline phosphatase, AFP alpha-fetoprotein, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, DCP decarboxylic prothrombin, CI confidence interval, OR odds ratio