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Table 2 Univariate and multivariate survival analysis for overall survival

From: Clinical characteristics and patient outcomes of molecular subtypes of small cell lung cancer (SCLC)

Variables

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Gender

1.523

0.489–4.746

0.468

   

Age

0.284

0.064–1.250

0.096

   

Smoking status

1.439

0.522–3.970

0.482

   

Tumor location

1.313

0.492–3.499

0.587

   

Histology

1.876

0.533–6.595

0.327

   

TNM stage

4.021

1.471–10.994

0.007

0.035

0.001–2.419

0.121

T stage

3.373

1.162–9.795

0.025

3.428

0.430–27.346

0.245

N stage

3.467

1.244–9.664

0.017

31.714

1.543–652.031

0.025

Ki-67 status

2.650

0.989–7.101

0.053

3.890

1.064–14.228

0.040

SCLC-A

0.985

0.357–2.718

0.977

   

SCLC-N

0.777

0.250–2.412

0.662

   

SCLC-P

2.617

0.887–7.727

0.082

7.582

1.321–43.504

0.023

SCLC-I

0.326

0.043–2.470

0.278

   

PD-L1 status

0.226

0.030–1.716

0.151

   

CD8 status

0.081

0.011–0.617

0.015

0.070

0.007–0.706

0.024

Adjuvant chemotherapy

0.351

0.131–0.936

0.036

0.369

0.090–1.514

0.166

Adjuvant radiotherapy

0.122

0.016–0.924

0.042

0.102

0.008–1.322

0.081

  1. Abbreviations: HR hazard ratio, CI confidence interval, TNM tumor-node-metastasis, SCLC small cell lung cancer, SCLC-A ASCL1-dominant SCLC, SCLC-N NEUROD1-dominant SCLC, SCLC-P POU2F3-dominant SCLC, SCLC-I triple negative or SCLC-inflamed SCLC, PD-L1 programmed death-ligand 1