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Table 2 Multivariate of the clinicopathological factors for progression-free survival and overall survival

From: Naples prognostic score, a novel prognostic score for patients with high- and intermediate-risk gastrointestinal stromal tumours after surgical resection

Characteristics

Progression-free survival

Overall survival

HR (95% CI)

P-value

HR (95% CI)

P-value

Age (years)

 

0.380

  

 ≤ 65

Reference

   

 > 65

0.855 (0.602–1.213)

   

Gender

 

0.606

  

 Female

Reference

   

 Male

1.096 (0.774–1.551)

   

BMI (kg/m2)

 

0.599

 

0.613

 BMI < 18.5

Reference

 

Reference

 

 18.5 ≤ BMI < 25

0.756 (0.345–1.658)

0.486

0.836 (0.339–2.062)

0.697

 BMI ≥ 25

0.680 (0.305–1.518)

0.347

0.680 (0.251–1.799)

0.428

Tumour location

 

< 0.001

 

< 0.001

 Non-gastric

Reference

 

Reference

 

 Gastric

0.523 (0.372–0.736)

 

0.409 (0.250–0.669)

 

Tumour size (cm)

 

0.002

 

0.018

 ≤ 10

Reference

 

Reference

 

 > 10

1.841 (1.255–2.700)

 

1.889 (1.113–3.206)

 

Mitotic index (per 50 HPF)

 

0.005

 

0.115

 0–5

Reference

 

Reference

 

 6–10

0.891 (0.582–1.365)

0.595

1.103 (0.609–1.995)

0.747

 > 10

1.752 (1.186–2.589)

0.005

1.749 (1.017–3.007)

0.043

Surgical approach

 

0.209

 

0.482

 Laparoscopy

Reference

 

Reference

 

 Open

1.413 (0.824–2.426)

 

1.355 (0.581–3.159)

 

Multi-organ involved

 

0.005

 

0.173

 No

Reference

 

Reference

 

 Yes

1.868 (1.208–2.889)

 

1.473 (0.844–2.570)

 

Blood transfusion

 

0.865

 

0.655

 No

Reference

 

Reference

 

 Yes

1.032 (0.721–1.476)

 

1.118 (0.686–1.821)

 

Postoperative imatinib

 

< 0.001

 

< 0.001

 No

Reference

 

Reference

 

 Yes

0.493 (0.350–0.696)

 

0.405 (0.246–0.669)

 

NPS group

 

< 0.001

 

< 0.001

 0

Reference

 

Reference

 

 1

4.622 (1.807–11.820)

0.001

1.945 (0.668–5.660)

0.222

 2

12.770 (4.932–33.059)

< 0.001

5.535 (1.923–15.929)

0.002

  1. Bold values indicate P < 0.05
  2. HPF high power field, NIH National Institutes of Health, NPS Naples prognostic score