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Table 3 Cases with appendiceal mucinous tumor and intussusception reported between January 2000 and February 2021

From: Multiple intestinal hemangioma concurrent with low-grade appendiceal mucinous neoplasm presenting as intussusception—a case report and literature review

Author

Patient

Presentation

Histology

Intussusception location

Preoperative diagnosis study

Treatment

Sex

Age

Chua et al [1]

F

30

Worsening right lower abdominal pain associated with nausea, vomiting, diarrhea

LAMN pTis

Ileocolic Intussusception

CT

Partial caecectomy with appendicectomy

Houlzé-Laroye [2]

F

35

Abdominal symptoms evoking an intestinal obstruction

LAMN pTis

Ileo-caecal intussusception (ileo-caecal intussusception through the left transverse colon)

CT

Exploratory laparotomy and bowel resection

Nakamatsu et al [3]

F

43

Right lower quadrant pain

LAMN pTis

Colonic intussusception located in the transverse colon

Contrast-enhanced CT, biopsy colonoscopy

Elective laparoscopy assisted ileocecal resection with lymph node dissection

Oliphant et al [4]

F

20

Colicky central abdominal pain, vomiting, constipation

LAMN pT3

Ileocolic Intussusception

CT

Extended right hemicolectomy

Coulier et al [5]

 

40

Intermittent right abdominal pain accompanied by a palpable mass in the right flank

LAMN pTis

Colo-colic intussusception with secondary ileocolic intussusception

Helical CT, US

Surgical reduction of the intussuscepting complex and ileo-cecal

Feliu et al [6]

F

57

Intermittent and worsening abdominal pain, dizziness, diarrhea

LAMN pTis

Ileocolic intussusception

X-ray, CT, laparoscopic

Right hemicolectomy

Cois et al [7]

F

36

Colicky pain located in the central abdomen, radiating to the flanks and associated with nausea

LAMN pTis

Right colonic intussusception

CT, US

Laparotomy, partial resection of the caecum and right ovary

Yamaguchi et al [8]

F

32

Intermittent abdominal pain and nonbloody diarrhea

LAMN pTis

Colic intussusception

X-ray, CT, colonoscopy, biopsy, barium enema

Laparoscopic reduction of intussusception and ileocecal resection

Rudek et al [9]

M

52

acute right lower abdominal pain

LAMN pTis

Appendix was partially intussuscepted into the cecum

Plain X-rays, US, CT

Ileocecal resection with regional lymphadenectomy, ileocolic anastomosis

Sun et al [10]

F

57

Hematochezia, changes in defecation habits, mild swelling and pain in the right lower quadrant of abdomen

LAMN pTis and rectal medium-low differentiated adenocarcinoma (cT4N1M0)

Appendix intussuscepted into the Cecum

CT, colonoscopy, biopsy

Resection of both the appendix and ileocecum, radical resection of the rectal Carcinoma, regular chemotherapy for rectal carcinoma

Okuda et al [11]

M

44

Asymptomatic

LAMN pTis

Ileocolic intussusception

US, reconstructed CT images, coronal and sagittal multiplanar reconstruction (MPR) images, MRI

Laparoscopic ileocecectomy

Lin et al [12]

M

28

Diffuse abdominal pain but more localized over the epigastric area and right lower quadrant with McBurney point tenderness

LAMN pT4a

Ileocolic intussusception

CT scan

Right hemicolectomy

Butte et al [13]

F

41

Episodic abdominal pain, abdominal distention and nausea

HAMN and well-differentiated neuroendocrine carcinoma

Distal ileum and appendix intussuscepted into the cecum

US, colonoscopy, CT, Biopsies

Right colectomy

Waseem et al [14]

F

84

Caecum intussuscepting into the transverse colon along with the appendix and ileum

LAMN pTis

Caecum intussuscepting into the transverse colon along with the appendix and ileum ileocaeco-colic intussusception

Plain radiographs, US

forceful reduction, Right hemicolectomy and ileocolic anastomosis

Teke et al [15]

F

37

Acute onset, right lower abdominal pain

LAMN pTis

Appendix intussuscepting into the caecum

CT

Ileocaecal resection

Laalim et al [16]

F

47

pain in the right side of the abdomen, nausea and vomiting

LAMN pTis

Appendiceal intussusception to the cecum and secondary distal ileum invagination

US, CT

Laparoscopic right hemicolectomy

Davey MG et al [17]

M

42

Sudden onset abdominal pain and bloody diarrhea

LAMN pTis

ileocecal intussusception at the hepatic flexure

Endoscopy, CT

Right hemicolectomy

Ashrafifi M et al [18]

M

35

Abdominal pain and an altered bowel habit., diarrhea, vomiting, and abdominal distension, anorexia

LAMN pT4a

Appendiceal intussusception to the cecum

Digital rectal examination and rigid sigmoidoscopy Colonoscopy, Biopsies, CT colonography

Appendicectomy, partial caecectomy

Blondiaux E et al [19]

F

63

Right lower quadrant abdominal pain

Simple retention cysts

Dilated proximal portion of the appendix intussuscepted in the cecum lumen

CT

Right hemi-colectomy

Siddiqi AJ et al [20]

F

22

Acute right lower quadrant pain

LAMN pTis

Ileocolic intussusception with an appendiceal mucocele serving as the lead point

Multidetector CT scan of the abdomen and pelvis

Appendectomy and ileocecal resection

Wong MT et al [21]

F

81

Intermittent right-sided abdominal pain

Simple retention cysts and Schistosomiasis

colonic intussusception

Digital rectal examination, plain abdominal radiographs, CT

Right hemicolectomy

Chan Ket et al [22]

F

41

Intermittent, right-sided abdominal pain, abdominal distension, nausea, and vomiting

LAMN pTis

Ileocolic intussusception

CT, Colonoscopy

Laparoscopic right hemicolectomy

Birkness J et al [23]

F

46

LAMN pTis

Appendiceal intussusception

Colonoscopy

Right colon resection

Birkness J et al [23]

F

64

LAMN pTis

Appendiceal intussusception

Colonoscopy

Cecal resection

Birkness J et al [23]

F

47

Serrated dysplasia, Low grade

Appendiceal intussusception

Colonoscopy

Right colon resection

  1. US ultrasound, CT computer tomography, − data not available, MRI magnetic resonance imaging, MRA magnetic resonance angiography, LAMN low-grade appendiceal mucinous neoplasms, HAMN high-grade appendiceal mucinous neoplasm
  2. LAMN pTis: LAMN confined to the muscularis propria (defined as involvement by acellular mucin or mucinous epithelium that may extend into muscularis propria)
  3. LAMN pT3: LAMNs invades subserosa or mesoappendix
  4. LAMN pT4a: LAMNs perforates visceral peritoneum, including mucinous peritoneal tumor or acellular mucin on the serosa of the appendix or mesoappendix
  5. LAMN pT4b: LAMNs directly invades other organs or structures