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Table 6 Significant factors affecting overall survival within 2 years by univariable and multivariable Cox proportional hazard model regression analysis

From: Long-term survival outcomes of esophageal cancer after minimally invasive Ivor Lewis esophagectomy

  Univariable   Multivariable  
Unadjusted HR
(95% CI)
p-value Adjusted HR
(95% CI)
p-value
Karnofsky performance status 0.955 (0.924–0.988) 0.007 0.959 (0.916–1.003) 0.070
ECOG performance status ≥ 1 2.715 (1.117–6.601) 0.028 2.849 (0.908–8.936) 0.073
National ADI≥ 90 based on index encounter address 3.266 (1.136–9.388) 0.028 0.374 (0.049–2.834) 0.341
Low socioeconomic status 2.477 (1.009–6.079) 0.048 1.131 (0.397–3.225) 0.818
pTNM stage IV 3.801 (1.441–10.026) 0.007 3.292 (1.042–10.408) 0.042*
Clavien-Dindo minor complications 2.254 (1.120–4.538) 0.023 2.063 (0.958–4.442) 0.064
Locoregional recurrence 2.029 (0.876–4.699) 0.099 1.244 (0.442–3.501) 0.679
Distant recurrence 5.430 (2.659–11.089) < 0.001* 5.784 (2.612–12.810) <0.001*
  1. HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; pTNM, pathological tumor-node-metastasis stage. Only significant variables on univariable analysis incorporated into multivariable model and summarized in the table. *Statistically significant values (p < 0.05)