Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age

Table 5 Univariate and multivariate analysis with respect to OS in younger and elderly patients

Parameters	Univarite analysis			Multivariate analysis
Parameters	Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
Age at opetation (years)
≤ 45 vs > 60	0.813	0.524–1.255	0.346
Tumor size (mm)
≤ 20 vs > 20	1.188	0.402–5.074	0.778
Skin infiltration
Negative vs positive	5.034	1.940–12.433	0.002	6.899	2.467–18.908	< 0.001
Lymph node status
Negative vs positive	4.239	1.227–26.631	0.019	2.999	0.815–19.389	0.106
Estrogen receptor
Negative vs positive	0.474	0.169–1.167	0.107
Progesterone receptor
Negative vs positive	0.475	0.137–1.285	0.151
Hormone receptor
Negative vs positive	0.441	0.157–1.085	0.076
HER2
Negative vs positive	0.283	0.066–0.844	0.021	0.721	0.149–2.809	0.645
Intrinsic subtype
Not TNBC vs TNBC	3.966	1.640–10.130	0.002	3.703	1.323–11.575	0.012
Ki67
≤ 14% vs >14%	2.730	1.004–9.518	0.049	2.271	0.768–8.314	0.144
Objective response rate
Non-responders vs responders	0.244	0.097–0.692	0.010	0.259	0.090–0.797	0.020
Pathological response
Non-pCR vs pCR	0.241	0.056–0.718	0.009	0.384	0.082–1.332	0.137
TILs
Low vs high	0.578	0.232–1.380	0.216

OS overall survival, CI confidence intervals, HER human epidermal growth factor receptor, pCR pathological complete response, TILs tumor-infiltrating lymphocytes

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