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Table 5 Univariate and multivariate analysis with respect to OS in younger and elderly patients

From: Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age

Parameters Univarite analysis Multivariate analysis
Hazard ratio 95% CI p value Hazard ratio 95% CI p value
Age at opetation (years)
 ≤ 45 vs > 60 0.813 0.524–1.255 0.346    
Tumor size (mm)
 ≤ 20 vs > 20 1.188 0.402–5.074 0.778    
Skin infiltration
 Negative vs positive 5.034 1.940–12.433 0.002 6.899 2.467–18.908 < 0.001
Lymph node status
 Negative vs positive 4.239 1.227–26.631 0.019 2.999 0.815–19.389 0.106
Estrogen receptor
 Negative vs positive 0.474 0.169–1.167 0.107    
Progesterone receptor
 Negative vs positive 0.475 0.137–1.285 0.151    
Hormone receptor
 Negative vs positive 0.441 0.157–1.085 0.076    
HER2
 Negative vs positive 0.283 0.066–0.844 0.021 0.721 0.149–2.809 0.645
Intrinsic subtype
 Not TNBC vs TNBC 3.966 1.640–10.130 0.002 3.703 1.323–11.575 0.012
Ki67
 ≤ 14% vs >14% 2.730 1.004–9.518 0.049 2.271 0.768–8.314 0.144
Objective response rate
 Non-responders vs responders 0.244 0.097–0.692 0.010 0.259 0.090–0.797 0.020
Pathological response
 Non-pCR vs pCR 0.241 0.056–0.718 0.009 0.384 0.082–1.332 0.137
TILs
 Low vs high 0.578 0.232–1.380 0.216    
  1. OS overall survival, CI confidence intervals, HER human epidermal growth factor receptor, pCR pathological complete response, TILs tumor-infiltrating lymphocytes