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Table 4 Univariate and multivariate analysis with respect to DFS in younger and elderly patients

From: Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age

Parameters

Univarite analysis

Multivariate analysis

Hazard ratio

95% CI

p value

Hazard ratio

95% CI

p value

Age at operation (years)

 ≤ 45 vs > 60

0.916

0.651–1.300

0.619

   

Tumor size (mm)

 ≤ 20 vs > 20

0.674

0.309–1.684

0.373

   

Skin infiltration

 Negative vs positive

2.629

1.140–5.582

0.025

2.597

1.075–5.858

0.035

Lymph node status

 Negative vs positive

4.935

1.756–20.600

0.001

3.981

1.385–16.828

0.008

Estrogen receptor

 Negative vs positive

0.738

0.358–1.469

0.390

   

Progesterone receptor

 Negative vs positive

0.733

0.322–1.524

0.418

   

Hormone receptor

 Negative vs positive

0.675

0.327–1.344

0.265

   

HER2

 Negative vs positive

0.237

0.070–0.602

0.001

0.479

0.130–1.423

0.193

Intrinsic subtype

 Not TNBC vs TNBC

2.710

1.356–5.392

0.005

2.418

1.080–5.456

0.032

Ki67

 ≤ 14% vs > 14%

2.339

1.066–5.872

0.033

2.489

1.089–6.417

0.030

Objective response rate

 Non-responders vs responders

0.309

0.145–0.734

0.010

0.381

0.159–0.984

0.047

Pathological response

 Non-pCR vs pCR

0.195

0.058–0.499

< 0.001

0.238

0.065–0.685

0.006

TILs

 Low vs high

0.523

0.253–1.045

0.066

0.991

0.431–2.231

0.982

  1. DFS disease-free survival, CI confidence intervals, HER human epidermal growth factor receptor, pCR pathological complete response, TILs tumor-infiltrating lymphocytes