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Table 4 Univariate and multivariate analysis with respect to DFS in younger and elderly patients

From: Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age

Parameters Univarite analysis Multivariate analysis
Hazard ratio 95% CI p value Hazard ratio 95% CI p value
Age at operation (years)
 ≤ 45 vs > 60 0.916 0.651–1.300 0.619    
Tumor size (mm)
 ≤ 20 vs > 20 0.674 0.309–1.684 0.373    
Skin infiltration
 Negative vs positive 2.629 1.140–5.582 0.025 2.597 1.075–5.858 0.035
Lymph node status
 Negative vs positive 4.935 1.756–20.600 0.001 3.981 1.385–16.828 0.008
Estrogen receptor
 Negative vs positive 0.738 0.358–1.469 0.390    
Progesterone receptor
 Negative vs positive 0.733 0.322–1.524 0.418    
Hormone receptor
 Negative vs positive 0.675 0.327–1.344 0.265    
HER2
 Negative vs positive 0.237 0.070–0.602 0.001 0.479 0.130–1.423 0.193
Intrinsic subtype
 Not TNBC vs TNBC 2.710 1.356–5.392 0.005 2.418 1.080–5.456 0.032
Ki67
 ≤ 14% vs > 14% 2.339 1.066–5.872 0.033 2.489 1.089–6.417 0.030
Objective response rate
 Non-responders vs responders 0.309 0.145–0.734 0.010 0.381 0.159–0.984 0.047
Pathological response
 Non-pCR vs pCR 0.195 0.058–0.499 < 0.001 0.238 0.065–0.685 0.006
TILs
 Low vs high 0.523 0.253–1.045 0.066 0.991 0.431–2.231 0.982
  1. DFS disease-free survival, CI confidence intervals, HER human epidermal growth factor receptor, pCR pathological complete response, TILs tumor-infiltrating lymphocytes