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Table 2 Main results of the association between VEGF and characteristics of patients with cholangiocarcinoma

From: The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Stratified analysis No. of studies No. of patients Pooled HR/OR (95% CI) p-value Heterogeneity
I2, % p-value Model
OS
 Overall 7 496 1.93 (1.52, 2.46) < 0.001 0 0.95 FEM
Clinicopathological features
 Age (> 60 vs. ≤ 60) 5 372 0.82 (0.49, 1.37) 0.45 0 0.70 FEM
 Gender (male vs. female) 5 339 0.77 (0.45, 1.33) 0.35 0 0.93 FEM
 LNM (yes vs. no) 7 496 6.79 (3.93, 11.73) < 0.001 0 1.00 FEM
 TNM stage (III–IV vs. I–II) 5 372 4.35 (1.48, 12.79) 0.007 58 0.05 REM
 Tumor size (> 5 cm vs. ≤ 5 cm) 4 322 0.96 (0.57, 1.63) 0.89 15 0.32 FEM
  1. CI confidence interval, HR hazard ratio, OR odds ratio, LNM lymph node metastasis, OS overall survival, TNM tumor node metastasis, vs versus, FEM fixed-effects model, REM random-effects model