Table 2 Main results of the association between VEGF and characteristics of patients with cholangiocarcinoma
Stratified analysis | No. of studies | No. of patients | Pooled HR/OR (95% CI) | p-value | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
I2, % | p-value | Model | |||||
OS | |||||||
Overall | 7 | 496 | 1.93 (1.52, 2.46) | < 0.001 | 0 | 0.95 | FEM |
Clinicopathological features | |||||||
Age (> 60 vs. ≤ 60) | 5 | 372 | 0.82 (0.49, 1.37) | 0.45 | 0 | 0.70 | FEM |
Gender (male vs. female) | 5 | 339 | 0.77 (0.45, 1.33) | 0.35 | 0 | 0.93 | FEM |
LNM (yes vs. no) | 7 | 496 | 6.79 (3.93, 11.73) | < 0.001 | 0 | 1.00 | FEM |
TNM stage (III–IV vs. I–II) | 5 | 372 | 4.35 (1.48, 12.79) | 0.007 | 58 | 0.05 | REM |
Tumor size (> 5 cm vs. ≤ 5 cm) | 4 | 322 | 0.96 (0.57, 1.63) | 0.89 | 15 | 0.32 | FEM |