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Table 1 Characteristics of the included studies in this meta-analysis

From: The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Study Year Country Cancer type Total Tumor stage Method Cutoff VEGF expression Survival analysis Multivariate analysis HR statistic HR (95% CI) Follow-up months NOS score
High expression High with LNM Low expression Low with LNM
Byung [14] 2006 Korea ICC 79 I–IV RT-qPCR Median 36 7 21 3 OS Rep SC 2.02 (1.18–3.46) 72 8
Liu [15] 2010 China ICC 86 I–IV RT-qPCR Median 69 27 11 1 OS NR SC 1.95 (0.73–5.16) 140 7
Shinichi [16] 2008 Japan ICC 62 I–IV RT-qPCR Mean 88 19 62 19 OS Rep SC 1.74 (1.07–2.82) 120 7
Wang [17] 2009 China ICC 130 I–IV RT-qPCR Median 69 27 11 1 OS NR SC 2.85 (1.08–7.56) 140 8
Xiao [18] 2012 China ICC 60 I–IV RT-qPCR Mean 47 19 11 2 OS NR SC 1.66(0.71–3.90) 60 7
Xu [19] 2015 China ICC 435 I–IV RT-qPCR Mean 65 13 27 2 OS Rep SC 3.003 (1.016–8.875) 100 8
Zhu [20] 2020 China ICC 102 I–IV RT-qPCR Median 122 73 21 5 OS NR SC 1.82 (1.17–2.82) 60 7
  1. ICC intrahepatic cholangiocarcinoma, HR hazard ratio, LNM lymph node metastasis, NR no report, OS overall survival, Rep report, RT-qPCR real-time quantitative polymerase chain reaction, SC survival curve, NOS Newcastle-Ottawa Scale