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Table 3 Predictive performance of CRP, PCT, and WBC for anastomotic leakage on isolated time points

From: Role of the triad of procalcitonin, C-reactive protein, and white blood cell count in the prediction of anastomotic leak following colorectal resections

Isolated time points

AUC

95% CI

Cutoff values

SN

SP

PPV

NPV

CRP (mg/L)

 POD 1

0.51

0.44–0.58

12.5

90.9

24.0

12.6

95.7

 POD 2

0.70*

0.63–0.76

62.6

81.8

67.2

23.1

96.9

 POD 3

0.76*

0.69–0.81

114.1

81.1

85.2

40.0

97.5

 POD 4

0.75*

0.68–0.81

168.4

72.7

94.5

61.5

96.6

 POD 5

0.68*

0.61–0.74

210.5

59.1

97.8

76.5

95.2

PCT (ng/mL)

 POD 1

0.73*

0.66–0.79

1.30

50.0

88.0

33.3

93.6

 POD 2

0.73*

0.67–0.79

1.89

63.6

86.3

35.9

95.2

 POD 3

0.84*

0.79–0.89

2.60

77.3

90.7

50.0

97.1

 POD 4

0.85*

0.80–0.90

3.65

72.7

94.5

61.5

96.6

 POD 5

0.89*

0.84–0.93

4.93

77.3

96.7

73.9

97.3

WBC (× 1000/mm3)

 POD 1

0.50

0.45–0.59

6.11

90.9

30.6

13.6

96.6

 POD 3

0.66*

0.59–0.73

7.50

91.0

41.5

15.7

97.4

 POD 5

0.79*

0.73–0.85

9.02

86.4

71.0

26.4

97.7

  1. CRP C-reactive protein, PCT procalcitonin, WBC white blood cell count, SN sensitivity, SP specificity, PPV positive predictive value, NPV negative predictive value, POD postoperative day
  2. *Statistically significant different AUC from the reference diagonal line at p values of less than 0.05