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Table 3 Predictive performance of CRP, PCT, and WBC for anastomotic leakage on isolated time points

From: Role of the triad of procalcitonin, C-reactive protein, and white blood cell count in the prediction of anastomotic leak following colorectal resections

Isolated time points AUC 95% CI Cutoff values SN SP PPV NPV
CRP (mg/L)
 POD 1 0.51 0.44–0.58 12.5 90.9 24.0 12.6 95.7
 POD 2 0.70* 0.63–0.76 62.6 81.8 67.2 23.1 96.9
 POD 3 0.76* 0.69–0.81 114.1 81.1 85.2 40.0 97.5
 POD 4 0.75* 0.68–0.81 168.4 72.7 94.5 61.5 96.6
 POD 5 0.68* 0.61–0.74 210.5 59.1 97.8 76.5 95.2
PCT (ng/mL)
 POD 1 0.73* 0.66–0.79 1.30 50.0 88.0 33.3 93.6
 POD 2 0.73* 0.67–0.79 1.89 63.6 86.3 35.9 95.2
 POD 3 0.84* 0.79–0.89 2.60 77.3 90.7 50.0 97.1
 POD 4 0.85* 0.80–0.90 3.65 72.7 94.5 61.5 96.6
 POD 5 0.89* 0.84–0.93 4.93 77.3 96.7 73.9 97.3
WBC (× 1000/mm3)
 POD 1 0.50 0.45–0.59 6.11 90.9 30.6 13.6 96.6
 POD 3 0.66* 0.59–0.73 7.50 91.0 41.5 15.7 97.4
 POD 5 0.79* 0.73–0.85 9.02 86.4 71.0 26.4 97.7
  1. CRP C-reactive protein, PCT procalcitonin, WBC white blood cell count, SN sensitivity, SP specificity, PPV positive predictive value, NPV negative predictive value, POD postoperative day
  2. *Statistically significant different AUC from the reference diagonal line at p values of less than 0.05