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Table 2 Univariate and multivariate analyses of overall survival for the SEER cohort

From: The value of tumor deposits in evaluating colorectal cancer survival and metastasis: a population-based retrospective cohort study

Variable Univariate Cox analysis Multivariate Cox analysis
HR(95% CI) p value HR(95% CI) p value
Age
 < 65 1 [Reference]   1 [Reference]  
 ≥ 65 1.936 (1.879–1.995) < 0.001 2.362 (2.291–2.436) < 0.001
Sex
 Male 1 [Reference]   1 [Reference]  
 Female 1.052 (1.024–1.081) < 0.001 1.104 (1.075–1.135) < 0.001
Race
 Other 1 [Reference]   1 [Reference]  
 White 1.260 (1.194–1.329) < 0.001 1.245 (1.180–1.314) < 0.001
 Black 1.440 (1.350–1.535) < 0.001 1.497 (1.404–1.596) < 0.001
AJCC
 I 1 [Reference]   1 [Reference]  
 II 1.642 (1.568–1.720) < 0.001 0.962 (0.881–1.051) 0.393
 III 2.333 (2.231–2.439) < 0.001 1.277 (1.147–1.423) < 0.001
 IV 7.674 (7.325–8.041) < 0.001 2.836 (2.532–3.176) < 0.001
T stage
 T1 1 [Reference]   1 [Reference]  
 T2 1.369 (1.278–1.467) < 0.001 1.220 (1.138–1.309) < 0.001
 T3 2.416 (2.281–2.559) < 0.001 1.696 (1.548–1.859) < 0.001
 T4 5.258 (4.948–5.586) < 0.001 2.647 (2.408–2.909) < 0.001
N stage     < 0.001
 N0 1 [Reference]   1 [Reference]  
 N1 1.663 (1.609–1.718) < 0.001 0.956 (0.885–1.032) 0.248
 N2 3.221 (3.117–3.328) < 0.001 1.365 (1.266–1.472) < 0.001
Primary site
 Rectum 1 [Reference]   1 [Reference]  
 Colon 1.326 (1.280–1.373) < 0.001 1.064 (1.026–1.103) 0.001
Grade     < 0.001
 I 1 [Reference]   1 [Reference]  
 II 1.289 (1.215–1.366) < 0.001 1.023 (0.965–1.086) 0.445
 III 2.225 (2.089–2.369) < 0.001 1.284 (1.204–1.370) < 0.001
 IV 2.554 (2.353–2.773) < 0.001 1.402 (1.289–1.524) < 0.001
TDs
 Negative 1 [Reference]   1 [Reference]  
 Positive 2.611 (2.526–2.699) < 0.001 1.346 (1.296–1.398) < 0.001
Perineural invasion
 Negative 1 [Reference]   1 [Reference]  
 Positive 2.143 (2.068–2.220) < 0.001 1.171 (1.127–1.216) < 0.001
Liver metastasis
 Negative 1 [Reference]   1 [Reference]  
 Positive 4.273 (4.126–4.425) < 0.001 1.318 (1.242–1.399) < 0.001
Lung metastasis
 Negative 1 [Reference]   1 [Reference]  
 Positive 4.232 (3.955–4.529) < 0.001 1.226 (1.139–1.319) < 0.001
Bone metastasis
 Negative 1 [Reference]   1 [Reference]  
 Positive 5.223 (4.422–6.168) < 0.001 1.368 (1.154–1.622) < 0.001
Brain metastasis
 Negative 1 [Reference]   1 [Reference]  
 Positive 6.603 (4.974–8.767) < 0.001 1.935 (1.452–2.579) < 0.001