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Table 2 Univariate and multivariate analyses of overall survival for the SEER cohort

From: The value of tumor deposits in evaluating colorectal cancer survival and metastasis: a population-based retrospective cohort study

Variable

Univariate Cox analysis

Multivariate Cox analysis

HR(95% CI)

p value

HR(95% CI)

p value

Age

 < 65

1 [Reference]

 

1 [Reference]

 

 ≥ 65

1.936 (1.879–1.995)

< 0.001

2.362 (2.291–2.436)

< 0.001

Sex

 Male

1 [Reference]

 

1 [Reference]

 

 Female

1.052 (1.024–1.081)

< 0.001

1.104 (1.075–1.135)

< 0.001

Race

 Other

1 [Reference]

 

1 [Reference]

 

 White

1.260 (1.194–1.329)

< 0.001

1.245 (1.180–1.314)

< 0.001

 Black

1.440 (1.350–1.535)

< 0.001

1.497 (1.404–1.596)

< 0.001

AJCC

 I

1 [Reference]

 

1 [Reference]

 

 II

1.642 (1.568–1.720)

< 0.001

0.962 (0.881–1.051)

0.393

 III

2.333 (2.231–2.439)

< 0.001

1.277 (1.147–1.423)

< 0.001

 IV

7.674 (7.325–8.041)

< 0.001

2.836 (2.532–3.176)

< 0.001

T stage

 T1

1 [Reference]

 

1 [Reference]

 

 T2

1.369 (1.278–1.467)

< 0.001

1.220 (1.138–1.309)

< 0.001

 T3

2.416 (2.281–2.559)

< 0.001

1.696 (1.548–1.859)

< 0.001

 T4

5.258 (4.948–5.586)

< 0.001

2.647 (2.408–2.909)

< 0.001

N stage

   

< 0.001

 N0

1 [Reference]

 

1 [Reference]

 

 N1

1.663 (1.609–1.718)

< 0.001

0.956 (0.885–1.032)

0.248

 N2

3.221 (3.117–3.328)

< 0.001

1.365 (1.266–1.472)

< 0.001

Primary site

 Rectum

1 [Reference]

 

1 [Reference]

 

 Colon

1.326 (1.280–1.373)

< 0.001

1.064 (1.026–1.103)

0.001

Grade

   

< 0.001

 I

1 [Reference]

 

1 [Reference]

 

 II

1.289 (1.215–1.366)

< 0.001

1.023 (0.965–1.086)

0.445

 III

2.225 (2.089–2.369)

< 0.001

1.284 (1.204–1.370)

< 0.001

 IV

2.554 (2.353–2.773)

< 0.001

1.402 (1.289–1.524)

< 0.001

TDs

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

2.611 (2.526–2.699)

< 0.001

1.346 (1.296–1.398)

< 0.001

Perineural invasion

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

2.143 (2.068–2.220)

< 0.001

1.171 (1.127–1.216)

< 0.001

Liver metastasis

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

4.273 (4.126–4.425)

< 0.001

1.318 (1.242–1.399)

< 0.001

Lung metastasis

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

4.232 (3.955–4.529)

< 0.001

1.226 (1.139–1.319)

< 0.001

Bone metastasis

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

5.223 (4.422–6.168)

< 0.001

1.368 (1.154–1.622)

< 0.001

Brain metastasis

 Negative

1 [Reference]

 

1 [Reference]

 

 Positive

6.603 (4.974–8.767)

< 0.001

1.935 (1.452–2.579)

< 0.001

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World Journal of Surgical Oncology

ISSN: 1477-7819

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