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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: miR-495-3p depresses cell proliferation and migration by downregulating HMGB1 in colorectal cancer

Fig. 3

HMGB1 is overexpressed in CRC and is the target gene of miR-495-3p. A Target genes of miR-495-3p were predicted using TargetScan and RNAhybrid. B The relative luciferase activity was measured by luciferase reporter assay. C Western blotting for HMGB1 protein levels following miR-495-3p mimic/inhibitor transfection. D HMGB1 mRNA levels in HT29 and SW480 cells after miR-495-3p knockdown and overexpression assessed by qRT-PCR. E TCGA database analysis of HMGB1 expression in CRC. F HMGB1 mRNA levels in 45 pairs of CRC tissues and their paracancer tissues assessed by qRT-PCR. G HMGB1 mRNA levels in HT29, SW480, SW620, HCT116 and FHC cells assessed by qRT-PCR. H Negative correlation between miR-495-3p and HMGB1 expression in 45 paired colorectal cancer specimens. *p < 0.05, **p < 0.01 and ***p < 0.001

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