Table 1 Clinicopathological parameters included in risk models for solitary fibrous tumor
Variable | Patients, n (%) | 5-year MFS (%) (95% CI) | Log-rank p value |
|---|---|---|---|
Age (years) | |||
< 55 (score 0) | 19 (44.2) | 100 (a) | 0.218 |
≥ 55 (score 1) | 24 (55.8) | 87.2 (60.2–96.8) | |
Sex | |||
Male | 21 (48.8) | 85.6 (56.1–96.5) | 0.121 |
Female | 22 (51.2) | 100 (a) | |
Location | |||
IT | 10 (23.3) | 100 (a) | 0.229 |
IA | 12 (27.9) | 87.5 (46.3–98.3) | |
CNS | 6 (14.0) | 100 (a) | |
Other | 15 (34.9) | 88.9 (50.0–98.5) | |
Tumor size (cm) | |||
0–4.9 (score 0) | 24 (55.8) | 100 (a) | 0.095 |
5–9.9 (score 1) | 10 (23.3) | 100 (a) | |
10–14.9 (score 2) | 3 (7.0) | 100 (a) | |
≥ 15 (score 3) | 6 (14.9) | 60.0 (20.0–90.0) | |
Mitoses/mm2 | |||
0 (score 0) | 34 (79.1) | 94.7 (70.6–99.3) | 0.982 |
0.5–1.5 (score 1) | 4 (9.3) | 100 (a) | |
≥ 2 (score 2) | 5 (11.6) | 66.7 (15.4–95.7) | |
Ki-67 LI (%) | |||
< 1 (score 0) | 15 (34.9) | 90.0 (53.3–98.6) | 0.018 |
1–10 (score 1) | 24 (55.8) | 100 (a) | |
≥ 10 (score 2) | 4 (9.3) | 50.0 (5.8–94.1) | |
Tumor necrosis (%) | |||
< 10 (score 0) | 40 (93.0) | 92.3 (73.5–98.1) | 0.978 |
≥ 10 (score 1) | 3 (7.0) | 100 (a) | |
Dedifferentiation | |||
Present | 2 (4.7) | 0 | 0.000 |
Absent | 41 (95.3) | 95.7 (74.8–99.4) | |
Three-variable risk model (age, size, mitoses) | |||
Low (0–2 points) | 33 (76.7) | 100 (a) | 0.049 |
Intermediate (3–4 points) | 7 (16.3) | 50.0 (5.9–94.1) | |
High (5–6 points) | 3 (7.0) | 66.7 (15.4–95.7) | |
Four-variable risk model (age, size, mitoses, necrosis) | |||
Low (0–3 points) | 37 (86.0) | 100 (a) | 0.060 |
Intermediate (4–5 points) | 4 (9.3) | 50.0 (5.9–94.1) | |
High (6–7 points) | 2 (4.7) | 50.0 (5.9–94.1) | |
Modified three-variable model (age, size, Ki-67 LI) | |||
Low risk (0–2 points) | 29 (67.4) | 100 (a) | 0.006 |
Intermediate/high risk (3–6 points) | 14 (32.6) | 74.1 (35.6–93.7) | |
Modified four-variable model (age, size, Ki-67 LI, necrosis) | |||
Low risk (0–3 points) | 35 (81.4) | 100 (a) | 0.022 |
Intermediate/high risk (4–7 points) | 8 (18.6) | 62.5 (21.9–90.9) | |