Table 3 Univariate survival analysis and multivariable analysis of patients with second primary renal cell carcinoma (2nd RCC)
From: A comprehensive analysis of renal cell carcinoma as first and second primary cancers
Overall survival | Univariate analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | |
Age (≥ 60) | 1.044 | 0.488–2.234 | 0.912 | 0.599 | 0.246–1.459 | 0.259 |
Gender (male) | 3.897 | 1.462–10.388 | 0.007 | 5.065 | 1.400–18.332 | 0.013 |
Smoking history (yes) | 1.653 | 0.763–3.580 | 0.202 | 0.721 | 0.244–2.133 | 0.555 |
Family history of tumor (yes) | 0.972 | 0.420–2.245 | 0.946 | 0.531 | 0.201–1.405 | 0.202 |
Primary non-renal malignancy (lung cancer) | 0.961 | 0.385–2.394 | 0.931 | 1.000 | 0.349–2.859 | 0.999 |
Symptoms (yes) | 7.073 | 2.354–21.251 | <0.001 | 5.217 | 0.726–37.501 | 0.101 |
Interval between first extrarenal malignancies and renal cell carcinoma (metachronous) | 0.685 | 0.297–1.582 | 0.376 | 0.719 | 0.278–1.862 | 0.497 |
Renal surgery (yes) | 0.151 | 0.05–0.457 | 0.001 | 0.329 | 0.069–1.578 | 0.165 |
Stage of RCC (≥T2) | 7.577 | 2.156–26.627 | 0.002 | 1.211 | 0.154–9.493 | 0.856 |