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Table 3 Univariate survival analysis and multivariable analysis of patients with second primary renal cell carcinoma (2nd RCC)

From: A comprehensive analysis of renal cell carcinoma as first and second primary cancers

Overall survival Univariate analysis Multivariable analysis
HR 95% CI p value HR 95% CI p value
Age (≥ 60) 1.044 0.488–2.234 0.912 0.599 0.246–1.459 0.259
Gender (male) 3.897 1.462–10.388 0.007 5.065 1.400–18.332 0.013
Smoking history (yes) 1.653 0.763–3.580 0.202 0.721 0.244–2.133 0.555
Family history of tumor (yes) 0.972 0.420–2.245 0.946 0.531 0.201–1.405 0.202
Primary non-renal malignancy (lung cancer) 0.961 0.385–2.394 0.931 1.000 0.349–2.859 0.999
Symptoms (yes) 7.073 2.354–21.251 <0.001 5.217 0.726–37.501 0.101
Interval between first extrarenal malignancies and renal cell carcinoma (metachronous) 0.685 0.297–1.582 0.376 0.719 0.278–1.862 0.497
Renal surgery (yes) 0.151 0.05–0.457 0.001 0.329 0.069–1.578 0.165
Stage of RCC (≥T2) 7.577 2.156–26.627 0.002 1.211 0.154–9.493 0.856
  1. RCC renal cell carcinoma