Table 1 Baseline clinicopathological characteristics of patients with ER+, Her2− breast cancer (n = 273)
Characteristic | n(%) | Overall | Breast | ||||
|---|---|---|---|---|---|---|---|
Total (n = 273) | pCR (n = 28) | Non-pCR (n = 245) | P valuea | pCR (n = 38) | Non-pCR (n = 235) | P value | |
Clinical variable | |||||||
Age (years) | 0.868 | 0.907 | |||||
< 45 | 84 (30.8) | 9 (32.1) | 75 (30.6) | 12 (31.6) | 72 (30.6) | ||
≥ 45 | 189 (69.2) | 19 (67.9) | 170 (69.4) | 26 (68.4) | 163 (69.4) | ||
BMI (kg/m2) | 0.975 | 0.388 | |||||
< 24 | 147 (53.8) | 15 (53.6) | 132 (53.9) | 18 (47.4) | 129 (54.9) | ||
≥ 24 | 126 (46.2) | 13 (46.4) | 113 (46.1) | 20 (52.6) | 106 (45.1) | ||
Tumor location | 0.822 | 0.935 | |||||
Left | 131 (48.0) | 14 (50.0) | 117 (47.8) | 18 (47.4) | 113 (48.1) | ||
Right | 142 (52.0) | 14 (50.0) | 128 (52.2) | 20 (52.6) | 122 (51.9) | ||
Menopausal status | 0.116 | 0.685 | |||||
Postmenopausal | 116 (42.5) | 8 (28.6) | 108 (44.1) | 15 (39.5) | 101 (43.0) | ||
Premenopausal | 157 (57.5) | 20 (71.4) | 137 (55.9) | 23 (60.5) | 134 (57.0) | ||
PLR | 0.242 | 0.069 | |||||
< 117.88 | 116 (42.5) | 9 (32.1) | 107 (43.7) | 11 (28.9) | 105 (44.7) | ||
≥ 117.88 | 157 (57.5) | 19 (67.9) | 138 (56.3) | 27 (71.1) | 130 (55.3) | ||
NLR | 0.067 | 0.283 | |||||
< 2.46 | 94 (34.4) | 14 (50.0) | 80 (32.7) | 16 (42.1) | 78 (33.2) | ||
≥ 2.46 | 179 (65.6) | 14 (50.0) | 165 (67.3) | 22 (57.9) | 157 (66.8) | ||
FBG | 0.392 | 0.225 | |||||
< 1.73 | 39 (14.3) | 2 (7.1) | 37 (15.1) | 35 (92.1) | 199 (84.7) | ||
≥ 1.73 | 234 (85.7) | 26 (92.9) | 208 (84.9) | 3 (7.9) | 36 (15.3) | ||
Tumor size (cm) | 0.988 | ||||||
< 2 | 35 (12.8) | 4 (14.3) | 31 (12.7) | 0.954 | 5 (13.2) | 30 (12.8) | |
2 ~ 5 | 195 (71.4) | 20 (71.4) | 175 (71.4) | 27 (71.1) | 168 (71.5) | ||
> 5 | 43 (15.8) | 4 (14.3) | 39 (15.9) | 6 (15.8) | 37 (15.7) | ||
Lymph node status | 0.854 | 0.406 | |||||
cN0 | 132 (48.4) | 14 (50.0) | 118 (48.2) | 16 (42.1) | 116 (49.4) | ||
cNX | 141 (51.6) | 14 (50.0) | 127 (51.8) | 22 (57.9) | 119 (50.6) | ||
Blood supply | 0.145 | 0.943 | |||||
Poor | 102 (37.4) | 14 (50.0) | 88 (35.9) | 14 (36.8) | 84 (37.4) | ||
Abundant | 171 (62.6) | 14 (50.0) | 157 (64.1) | 24 (63.2) | 147 (62.6) | ||
Pathological variable | |||||||
Histological grade | 0.038 | 0.009 | |||||
I | 20 (7.3) | 1 (3.6) | 19 (7.8) | 2 (5.3) | 18 (7.7) | ||
II | 229 (83.9) | 21 (75.0) | 208 (84.9) | 27 (71.1) | 202 (84.0) | ||
III | 24 (8.8) | 6 (21.4) | 18 (7.3) | 9 (23.6) | 15 (6.3) | ||
ER (%) | 0.002 | 0.005 | |||||
[1, 10] | 16 (5.9) | 5 (17.9) | 11 (4.5) | 6 (15.8) | 10 (4.3) | ||
[10, 30] | 17 (6.2) | 2 (7.1) | 15 (6.1) | 4 (10.5) | 13 (5.5) | ||
[30, 50] | 30 (11.0) | 7 (25.0) | 23 (9.4) | 8 (21.1) | 22 (9.4) | ||
[50, 70] | 60 (22.0) | 6 (21.4) | 54 (22.0) | 8 (21.1) | 52 (22.1) | ||
> 70 | 150 (54.9) | 8 (28.6) | 142 (58.0) | 12 (31.5) | 138 (58.7) | ||
PgR(%) | 0.003 | <0.001 | |||||
Negative | 62 (22.7) | 8 (28.6) | 54 (22.0) | 12 (31.6) | 50 (21.3) | ||
[1, 10] | 40 (14.7) | 10 (35.7) | 30 (12.3) | 13 (34.2) | 27 (11.5) | ||
> 10 | 171 (62.6) | 10 (35.7) | 161 (65.7) | 13 (34.2) | 158 (67.2) | ||
Ki-67(%) | 0.005 | <0.001 | |||||
< 20 | 101 (37.0) | 3 (10.7) | 98 (40.0) | 5 (13.2) | 96 (40.9) | ||
[20, 40) | 110 (40.3) | 13 (46.4) | 97 (39.6) | 15 (39.4) | 95 (40.3) | ||
[40, 60) | 43 (15.8) | 8 (28.6) | 35 (14.3) | 13 (34.2) | 30 (12.8) | ||
≥ 60 | 19 (7.0) | 4 (14.3) | 15 (6.1) | 5 (13.2) | 14 (6.0) | ||
P53 status | 0.424 | 0.163 | |||||
Negative | 76 (27.8) | 6 (21.4) | 70 (28.6) | 7 (18.4) | 69 (29.4) | ||
Positive | 197 (72.2) | 22 (78.6) | 175 (71.4) | 31 (81.6) | 166 (70.6) | ||