Table 1 Statistical association of EpCAM and CD166 expression with clinicopathological parameters in colorectal cancer specimens (Pearson χ2). The bold values are statistically significant
Variables | Total no. (%) | EpCAM expression (mean H-score = 196) | P value | CD166 expression (mean H-score = 83) | P value | ||
|---|---|---|---|---|---|---|---|
Low | High | Low | High | ||||
Mean age years | |||||||
 60 ≥ | 241 (52.5) | 72 (34) | 140 (66) | 0.03 | 127 (60) | 85 (40) | 0.47 |
 60 < | 218 (47.5) | 88 (43) | 115 (57) | 114 (59) | 79 (41) | ||
Gender | |||||||
 Male | 236 (51.5) | 87 (40) | 130 (60) | 0.26 | 117 (56) | 92 (44) | 0.08 |
 Female | 222 (48.5) | 72 (36.5) | 125 (63.5) | 123 (63) | 79 (37) | ||
Tumor size (cm) | |||||||
 5 ≥ | 300 (66) | 96 (35) | 175 (65) | 0.02 | 158 (59) | 109 (41) | 0.5 |
 5 < | 154 (34) | 64 (46) | 76 (54) | 78 (58.5) | 55 (41.5) | ||
TNM stage | |||||||
 I | 71 (16) | 20 (31) | 45 (69) | 0.007 | 46 (70) | 20 (30) | 0.2 |
 IIA | 172 (38) | 48 (30.5) | 109 (69.5) | 81 (52.5) | 73 (47.5) | ||
 IIB | 21 (5) | 9 (45) | 11 (55) | 12 (60) | 8 (40) | ||
 IIIA | 76 (17) | 36 (53) | 32 (47) | 33 (53) | 29 (47) | ||
 IIIB | 68 (15) | 29 (48) | 31 (52) | 39 (68.5) | 18 (31.5) | ||
 IIIC | 17 (4) | 9 (60) | 6 (40) | 9 (69) | 4 (31) | ||
 IVA | 21 (5) | 7 (36.5) | 12 (63.5) | 14 (67) | 7 (33) | ||
Tumor location | |||||||
 Cecum | 70 (16.5) | 29 (44) | 37 (56) | 0.09 | 37 (58) | 27 (42) | 0.29 |
 Sigmoid | 140 (34) | 36 (28) | 92 (72) | 73 (58.5) | 52 (41.5) | ||
 Rectom | 114 (27) | 45 (48.5) | 48 (51.5) | 64 (69) | 29 (31) | ||
 Colon ascending | 34 (8) | 11 (34.5) | 21 (65.5) | 20 (67) | 10 (33) | ||
 Colon transvers | 29 (7) | 9 (32) | 19 (68) | 13 (46.5) | 15 (53.5) | ||
 Colon descending | 12 (3) | 5 (45.5) | 6 (54.5) | 5 (42) | 7 (58) | ||
 Rectosigmoid | 18 (4.5) | 8 (44.5) | 10 (55.5) | 11 (65) | 6 (35) | ||
Tumor differentiation | |||||||
 Well | 165 (36.5) | 45 (30) | 103 (70) | 0.005 | 93 (63) | 55 (37) | 0.17 |
 Moderate/poor | 289 (63.5) | 115 (43.5) | 148 (56.5) | 145 (57.5) | 107 (42.5) | ||
Distant metastasis | |||||||
 Positive | 25 (6) | 7 (30) | 16 (70) | 0.29 | 17 (68) | 8 (32) | 0.24 |
 Negative | 416 (94) | 146 (38.5) | 232 (61.5) | 215 (59) | 150 (41) | ||
Neural invasion | |||||||
 Positive | 90 (20) | 41 (52.5) | 38 (47.5) | 0.01 | 47 (69) | 22 (31) | 0.15 |
 Negative | 355 (80) | 113 (35) | 212 (65) | 188 (58) | 138 (42) | ||
Vascular invasion | |||||||
 Positive | 69 (15.5) | 30 (52.5) | 27 (47.5) | 0.01 | 37 (65) | 20 (35) | 0.25 |
 Negative | 379 (84.5) | 124 (35.5) | 224 (64.5) | 201 (59) | 139 (41) | ||
Lymph node invasion | |||||||
 Positive | 171 (37.5) | 74 (48.5) | 78 (51.5) | 0.001 | 89 (61.5) | 56 (38.5) | 0.31 |
 Negative | 286 (62.5) | 84 (32) | 177 (68) | 151 (58) | 108 (42) | ||