Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review

Table 2 Characteristics of the studies eligible for meta-analysis

Frist author	Year	Country	Source of control	Genotyping method	Case/control	Case					Control					HWE*
MiRNA-146a rs2910164	Year	Country	Source of control	Genotyping method	Case/control	CC	CG	GG	C	G	CC	CG	GG	C	G	HWE*
Bin Zhou	2011	China	HB*	PCR-RFLP*	226/309	70	113	43	253	199	116	159	34	391	227	0.060
Cong Yue	2011	China	HB*	PCR-RFLP*	447/443	105	224	118	434	460	150	206	87	506	380	0.285
Li Ma	2015	China	HB*	PCR-RFLP*	205/415	53	102	50	208	202	103	219	93	425	405	0.254
ShiZhi Wang	2019	China	HB*	TaqMan	954/1339	318	475	141	1111	757	471	631	212	1573	1055	0.978
Nisha Thakur	2019	India	HB*	PCR-RFLP*	150/150	21	49	80	91	209	28	49	73	105	195	0.056
MiRNA-499 rs3746444						TT	CT	CC	T	C	TT	CT	CC	T	C
Bin Zhou	2011	China	HB*	PCR-RFLP*	226/309	134	84	8	352	100	223	71	15	517	101	0.051
ShiZhi Wang	2019	China	HB*	TaqMan	954/1339	675	228	27	1578	282	946	339	35	2231	409	0.485
Nisha Thakur	2019	India	HB*	PCR-RFLP*	150/150	25	47	78	97	203	21	49	80	91	209	0.063
MiRNA-196a2 rs11614913						TT	CT	CC	T	C	TT	CT	CC	T	C
Bin Zhou	2011	China	HB*	PCR-RFLP*	226/309	57	123	46	237	215	82	169	58	333	285	0.077
Bo Ding	2016	China	HB*	TaqMan*	509/562	133	265	111	531	487	181	278	103	640	484	0.836
ChunTao Wang	2016	China	HB*	PCR-LDR*	104/186	31	52	21	114	94	65	82	39	212	160	0.170
ZhiLing Yan	2019	China	HB*	TaqMan	547/567	117	277	153	511	583	153	282	132	588	546	0.926
ShiZhi Wang	2019	China	HB*	TaqMan	954/1339	271	464	194	1006	852	424	629	269	1477	1167	0.201
Nisha Thakur	2019	India	HB*	PCR-RFLP*	150/150	17	58	75	92	208	57	51	42	165	135	0.089

Note: HWE Hardy-Weinberg equilibrium, HB hospital-based, PCR-RFLP restriction fragment length polymorphism polymerase chain reaction, PCR-LDR polymerase chain reaction-ligase detection reaction

ISSN: 1477-7819