Table 3 The KEGG pathway analysis of activated memory CD4 T cells and CD8 T cell-related genes in the Comparative Toxicogenomics Database. The KEGG pathway analysis of CD8 T cell-related genes

Th17 cell differentiation

4.53E-24

4.53E-24

2.55E-22

TBX21/IL12RB1/ZAP70/CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD3E/IL21R/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/CD247/HLA-DQA1/CD3G/IL2RG/GATA3/IRF4/IL2RA

Th1 and Th2 cell differentiation

2.90E-24

2.90E-24

2.55E-22

TBX21/IL12RB1/ZAP70/CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/RUNX3/CD3E/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/CD247/HLA-DQA1/CD3G/IL2RG/GATA3/IL2RA

Cell adhesion molecules (CAMs)

8.08E-17

8.08E-17

3.03E-15

CD8B/CD8A/CTLA4/TIGIT/ICOS/PDCD1/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD2/HLA-DRB5/HLA-DMB/HLA-DOA/CD6/ICAM3/HLA-DQA1/CD226/CD86/SELPLG

Cytokine-cytokine receptor interaction

6.07E-10

6.07E-10

3.42E-09

CCL4/CXCL9/CCL5/CD27/IL12RB1/CXCR3/CXCR6/CCR5/TNFRSF8/IL21R/IL2RB/CXCL13/IL10RA/CCR2/IL18RAP/CXCL11/TNFRSF17/IL2RG/IL16/IL2RA

Human T cell leukemia virus 1 infection

2.30E-10

2.30E-10

1.44E-09

CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/PIK3CD/CD3E/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/HLA-DQA1/CD3G/IL2RG/IL2RA

Hematopoietic cell lineage

3.87E-15

3.87E-15

7.27E-14

CD8B/CD8A/CD3D/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD2/CD3E/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/CD3G/IL2RA

Epstein-Barr virus infection

4.09E-09

4.09E-09

2.00E-08

CD3D/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/RUNX3/PIK3CD/CD3E/HLA-DRB5/JAK3/HLA-DMB/HLA-DOA/CD247/HLA-DQA1/CD3G

Inflammatory bowel disease (IBD)

1.70E-15

1.70E-15

4.77E-14

TBX21/IL12RB1/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/IL21R/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/IL18RAP/IL2RG/GATA3

T cell receptor signaling pathway

2.60E-12

2.60E-12

3.67E-11

CD8B/CD8A/CTLA4/ZAP70/ICOS/PDCD1/CD3D/LCK/PIK3CD/CD3E/LCP2/ITK/CD247/VAV1/CD3G

Systemic lupus erythematosus

9.81E-11

9.81E-11

7.17E-10

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/C1QB/C1QA/C1QC/HLA-DRB5/FCGR3A/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/CD86

Tuberculosis

7.02E-09

7.02E-09

3.29E-08

CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/HLA-DRB5/FCGR3A/HLA-DMB/CORO1A/HLA-DOA/IL10RA/HLA-DQA1/FCGR1A

Chemokine signaling pathway

1.37E-08

1.37E-08

6.16E-08

CCL4/CXCL9/CCL5/CXCR3/CXCR6/CCR5/PIK3CD/JAK3/GNGT2/CXCL13/ITK/VAV1/CCR2/CXCL11/DOCK2

Antigen processing and presentation

1.24E-11

1.24E-11

1.55E-10

CD8B/CD8A/CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1

Phagosome

5.66E-08

5.66E-08

2.36E-07

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/FCGR3A/HLA-DMB/CORO1A/HLA-DOA/HLA-DQA1/FCGR1A/NCF2

Herpes simplex virus 1 infection

0.00945

0.00945

0.02596

CCL5/CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/PIK3CD/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/POU2F2

Intestinal immune network for IgA production

6.14E-13

6.14E-13

9.88E-12

ICOS/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86/TNFRSF17

Leishmaniasis

1.82E-10

1.82E-10

1.21E-09

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/FCGR3A/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/NCF2

Rheumatoid arthritis

1.75E-09

1.75E-09

9.36E-09

CTLA4/CCL5/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Toxoplasmosis

1.52E-08

1.52E-08

6.56E-08

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/CCR5/HLA-DRB5/HLA-DMB/HLA-DOA/IL10RA/HLA-DQA1

Influenza A

1.52E-06

1.52E-06

5.91E-06

CCL5/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/PIK3CD/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1

Autoimmune thyroid disease

4.21E-11

4.21E-11

3.95E-10

CTLA4/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Osteoclast differentiation

6.09E-07

6.09E-07

2.45E-06

SIRPG/LILRB2/LCK/LILRB1/PIK3CD/FCGR3A/LCP2/FCGR1A/LILRA1/LILRA5/NCF2

Allograft rejection

2.62E-11

2.62E-11

2.68E-10

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Graft-versus-host disease

6.01E-11

6.01E-11

5.21E-10

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Type I diabetes mellitus

1.01E-10

1.01E-10

7.17E-10

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Viral myocarditis

3.31E-09

3.31E-09

1.69E-08

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86

Asthma

1.02E-10

1.02E-10

7.17E-10

HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1

Chagas disease (American trypanosomiasis)

5.47E-06

5.47E-06

2.05E-05

CCL5/CD3D/C1QB/PIK3CD/C1QA/CD3E/C1QC/CD247/CD3G

Natural killer cell mediated cytotoxicity

0.000256

0.000256

0.000875

ZAP70/SH2D1A/LCK/PIK3CD/FCGR3A/LCP2/CD247/VAV1

Measles

0.000366

0.000366

0.001211

CD3D/PIK3CD/CD3E/JAK3/IL2RB/CD3G/IL2RG/IL2RA

JAK-STAT signaling pathway

0.001058

0.001058

0.003309

IL12RB1/PIK3CD/IL21R/JAK3/IL2RB/IL10RA/IL2RG/IL2RA

B cell receptor signaling pathway

7.87E-05

7.87E-05

0.000277

CD72/LILRB2/LILRB1/PIK3CD/VAV1/LILRA1/LILRA5

Toll-like receptor signaling pathway

0.002081

0.002081

0.006167

CCL4/CXCL9/CCL5/PIK3CD/CD86/CXCL11

Fc gamma R-mediated phagocytosis

0.006618

0.006618

0.019112

PIK3CD/FCGR3A/VAV1/FCGR1A/DOCK2

Prion diseases

0.000973

0.000973

0.00313

CCL5/C1QB/C1QA/C1QC

Cytosolic DNA-sensing pathway

0.008425

0.008425

0.023723

CCL4/CCL5/ZBP1/AIM2