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Table 3 The KEGG pathway analysis of activated memory CD4 T cells and CD8 T cell-related genes in the Comparative Toxicogenomics Database. The KEGG pathway analysis of CD8 T cell-related genes

From: Screening and analysis of RNAs associated with activated memory CD4 and CD8 T cells in liver cancer

Description p value p.adjust q value gene_symbol
Th17 cell differentiation 4.53E-24 4.53E-24 2.55E-22 TBX21/IL12RB1/ZAP70/CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD3E/IL21R/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/CD247/HLA-DQA1/CD3G/IL2RG/GATA3/IRF4/IL2RA
Th1 and Th2 cell differentiation 2.90E-24 2.90E-24 2.55E-22 TBX21/IL12RB1/ZAP70/CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/RUNX3/CD3E/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/CD247/HLA-DQA1/CD3G/IL2RG/GATA3/IL2RA
Cell adhesion molecules (CAMs) 8.08E-17 8.08E-17 3.03E-15 CD8B/CD8A/CTLA4/TIGIT/ICOS/PDCD1/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD2/HLA-DRB5/HLA-DMB/HLA-DOA/CD6/ICAM3/HLA-DQA1/CD226/CD86/SELPLG
Cytokine-cytokine receptor interaction 6.07E-10 6.07E-10 3.42E-09 CCL4/CXCL9/CCL5/CD27/IL12RB1/CXCR3/CXCR6/CCR5/TNFRSF8/IL21R/IL2RB/CXCL13/IL10RA/CCR2/IL18RAP/CXCL11/TNFRSF17/IL2RG/IL16/IL2RA
Human T cell leukemia virus 1 infection 2.30E-10 2.30E-10 1.44E-09 CD3D/LCK/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/PIK3CD/CD3E/HLA-DRB5/JAK3/HLA-DMB/IL2RB/HLA-DOA/HLA-DQA1/CD3G/IL2RG/IL2RA
Hematopoietic cell lineage 3.87E-15 3.87E-15 7.27E-14 CD8B/CD8A/CD3D/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CD2/CD3E/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/CD3G/IL2RA
Epstein-Barr virus infection 4.09E-09 4.09E-09 2.00E-08 CD3D/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/RUNX3/PIK3CD/CD3E/HLA-DRB5/JAK3/HLA-DMB/HLA-DOA/CD247/HLA-DQA1/CD3G
Inflammatory bowel disease (IBD) 1.70E-15 1.70E-15 4.77E-14 TBX21/IL12RB1/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/IL21R/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/IL18RAP/IL2RG/GATA3
T cell receptor signaling pathway 2.60E-12 2.60E-12 3.67E-11 CD8B/CD8A/CTLA4/ZAP70/ICOS/PDCD1/CD3D/LCK/PIK3CD/CD3E/LCP2/ITK/CD247/VAV1/CD3G
Systemic lupus erythematosus 9.81E-11 9.81E-11 7.17E-10 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/C1QB/C1QA/C1QC/HLA-DRB5/FCGR3A/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/CD86
Tuberculosis 7.02E-09 7.02E-09 3.29E-08 CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/HLA-DRB5/FCGR3A/HLA-DMB/CORO1A/HLA-DOA/IL10RA/HLA-DQA1/FCGR1A
Chemokine signaling pathway 1.37E-08 1.37E-08 6.16E-08 CCL4/CXCL9/CCL5/CXCR3/CXCR6/CCR5/PIK3CD/JAK3/GNGT2/CXCL13/ITK/VAV1/CCR2/CXCL11/DOCK2
Antigen processing and presentation 1.24E-11 1.24E-11 1.55E-10 CD8B/CD8A/CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1
Phagosome 5.66E-08 5.66E-08 2.36E-07 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/FCGR3A/HLA-DMB/CORO1A/HLA-DOA/HLA-DQA1/FCGR1A/NCF2
Herpes simplex virus 1 infection 0.00945 0.00945 0.02596 CCL5/CD74/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/PIK3CD/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/POU2F2
Intestinal immune network for IgA production 6.14E-13 6.14E-13 9.88E-12 ICOS/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86/TNFRSF17
Leishmaniasis 1.82E-10 1.82E-10 1.21E-09 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/FCGR3A/HLA-DMB/HLA-DOA/HLA-DQA1/FCGR1A/NCF2
Rheumatoid arthritis 1.75E-09 1.75E-09 9.36E-09 CTLA4/CCL5/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Toxoplasmosis 1.52E-08 1.52E-08 6.56E-08 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/CCR5/HLA-DRB5/HLA-DMB/HLA-DOA/IL10RA/HLA-DQA1
Influenza A 1.52E-06 1.52E-06 5.91E-06 CCL5/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/CIITA/PIK3CD/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1
Autoimmune thyroid disease 4.21E-11 4.21E-11 3.95E-10 CTLA4/HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Osteoclast differentiation 6.09E-07 6.09E-07 2.45E-06 SIRPG/LILRB2/LCK/LILRB1/PIK3CD/FCGR3A/LCP2/FCGR1A/LILRA1/LILRA5/NCF2
Allograft rejection 2.62E-11 2.62E-11 2.68E-10 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Graft-versus-host disease 6.01E-11 6.01E-11 5.21E-10 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Type I diabetes mellitus 1.01E-10 1.01E-10 7.17E-10 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Viral myocarditis 3.31E-09 3.31E-09 1.69E-08 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1/CD86
Asthma 1.02E-10 1.02E-10 7.17E-10 HLA-DPB1/HLA-DQB1/HLA-DRA/HLA-DPA1/HLA-DRB1/HLA-DRB5/HLA-DMB/HLA-DOA/HLA-DQA1
Chagas disease (American trypanosomiasis) 5.47E-06 5.47E-06 2.05E-05 CCL5/CD3D/C1QB/PIK3CD/C1QA/CD3E/C1QC/CD247/CD3G
Natural killer cell mediated cytotoxicity 0.000256 0.000256 0.000875 ZAP70/SH2D1A/LCK/PIK3CD/FCGR3A/LCP2/CD247/VAV1
Measles 0.000366 0.000366 0.001211 CD3D/PIK3CD/CD3E/JAK3/IL2RB/CD3G/IL2RG/IL2RA
JAK-STAT signaling pathway 0.001058 0.001058 0.003309 IL12RB1/PIK3CD/IL21R/JAK3/IL2RB/IL10RA/IL2RG/IL2RA
B cell receptor signaling pathway 7.87E-05 7.87E-05 0.000277 CD72/LILRB2/LILRB1/PIK3CD/VAV1/LILRA1/LILRA5
Toll-like receptor signaling pathway 0.002081 0.002081 0.006167 CCL4/CXCL9/CCL5/PIK3CD/CD86/CXCL11
Fc gamma R-mediated phagocytosis 0.006618 0.006618 0.019112 PIK3CD/FCGR3A/VAV1/FCGR1A/DOCK2
Prion diseases 0.000973 0.000973 0.00313 CCL5/C1QB/C1QA/C1QC
Cytosolic DNA-sensing pathway 0.008425 0.008425 0.023723 CCL4/CCL5/ZBP1/AIM2