Fig. 6

Chemical small-molecule–target network analysis of activated memory CD4 T cells and CD8 T cell-related genes. To search for liver cancer-related genes and chemicals, the Comparative Toxicogenomics Database was searched using “Carcinoma, Hepatocellular” as keywords. Genes that were both associated with liver cancer, and belonged to the T cell-related genes ceRNA network, were used to screen chemical-target pairs. The T cell-related genes chemical small-molecule–target network was obtained utilizing the Cytoscape software. There were 44 chemical small-molecule–target interaction pairs associated with activated memory CD4 T cells, including five mRNAs and 26 chemical small molecules. In addition, there were 276 CD8 T cell-associated chemical small-molecule–target interaction pairs, containing 19 mRNAs and 110 chemical small molecules. A The chemical small-molecule–target network of genes in activated memory CD4 T cells. B The chemical small-molecule–target network of genes in CD8 T cells. Red nodes represent survival-related upregulated DEGs, and green nodes represent chemical small molecules. The size of nodes represents the value, such that larger nodes indicate a larger value