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Fig. 3 | World Journal of Surgical Oncology

Fig. 3

From: Screening and analysis of RNAs associated with activated memory CD4 and CD8 T cells in liver cancer

Fig. 3

Enrichment analysis of activated memory CD4 T cells and CD8 T cell-related genes. The clusterProfiler package in R was used to perform GO and KEGG pathway enrichment analysis with a cutoff of P < 0.05 and count ≥ 2. In the enrichment analysis of activated memory CD4 T cells and CD8 T cell-related genes, activated memory CD4 T cell-related genes were enriched in 406 GO-BPs (e.g., regulation of lymphocyte activation, regulation of T cell activation, and regulation of cell-cell adhesion) and 35 KEGG pathways [e.g., CAMs, Th1 and Th2 cell differentiation and Hematopoietic cell lineage]. In addition, CD8 T cell-related genes were involved in 596 GO-BPs (e.g., regulation of lymphocyte activation, regulation of T cell activation, and regulation of cell-cell adhesion) and 42 KEGG pathways [e.g., Th17 cell differentiation, Th1 and Th2 cell differentiation, and CAMs]. A The GO analysis of activated memory CD4 T cell-related genes. B The GO analysis of CD8 T cell-related genes. C The KEGG pathways analysis activated memory CD4 T cell-related genes. D The KEGG pathways analysis CD8 T cell-related genes. The size of the ball represents the number of genes enriched in each term. The color of the ball represents the value of the P value. GO, Gene Ontology; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes

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