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Fig. 1 | World Journal of Surgical Oncology

Fig. 1

From: Screening and analysis of RNAs associated with activated memory CD4 and CD8 T cells in liver cancer

Fig. 1

Differentially expressed genes (DEGs) between the high and low stromal and immune score groups. Based on the median value of stromal and immune scores of all tumor samples, the tumor samples were divided into high- and low-score groups. The standard Bayesian modified t test in the limma package was applied to analyze differentially expressed RNAs (DERNA) between high and low immune-score groups with a cutoff of |logFC| > 1 and P < 0.05. According to the stromal score, there were 55,955 DEGs (2279 upregulated and 153 downregulated) were selected between high and low stromal-score groups. Meanwhile, 1811 DEGs (including 1744 upregulated and 67 downregulated) were selected according to the high and low immune-score groups. In addition, there were 1211 upregulated overlapped DEGs and 27 downregulated overlapped DEGs were selected in the stromal score and immune score groups. In the enrichment analysis of 1238 overlapped DEGs, the GO analysis showed that the 1238 DEGs were mainly enriched in 1457 GO-BPs and 74 KEGG pathways. A The DEGs between high and low stromal-score groups. B The DEGs between high and low immune-score groups. C The upregulated DEGs in the stromal score and immune score groups. D: The downregulated DEGs in the stromal score and immune score groups. E The GO analysis of all overlapped DEGs. F The KEGG pathways analysis of all overlapped DEGs. Red nodes represent upregulated DEGs and blue nodes represent downregulated DEGs. The size of the ball represents the number of genes enriched in each term. The color of the ball represents the value of the P value. DEGs: differentially expressed genes; GO, Gene Ontology; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes

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