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Table 1 Comparison of patient demographics and clinicopathological features of the two datasets

From: CT radiomics nomogram for the preoperative prediction of severe post-hepatectomy liver failure in patients with huge (≥ 10 cm) hepatocellular carcinoma

Variable Training dataset
(n = 131)
Test dataset
(n = 55)
p value
Sex, n (%) 0.363
 Male 118 (90.08) 47 (85.46)
 Female 13 (9.92) 8 (14.54)
Age, years 58.69 ± 11.13 53.25 ± 17.19 0.387
BMI, kg/m2 23.97 ± 3.79 23.89 ± 4.01 0.963
HBsAg positive, n (%) 104 (79.38) 36 (65.45) 0.044
Child-Pugh class, n (%) 0.923
 A 115 (87.79) 48 (87.27)
 B 16(12.21) 7(12.72)
AFP, median (IQR), ng/ml 38.7 (4–3849) 171.5 (9–9312) 0.717
Liver function tests
 ALB (g/L) 38.07 ± 4.84 37.55 ± 6.57 0.837
 TBIL (μmol/L) 16.07 ± 8.75 18.94 ± 12.43 0.541
 ALT (U/L) 48.00 ± 53.05 58.88 ± 47.64 0.641
 AST (U/L) 81.23 ± 63.99 75.75 ± 66.02 0.853
 GGT(U/L) 130.62 ± 109.54 167.13 ± 166.12 0.549
 Cr (μmol/L) 50.46 ± 11.81 55.63 ± 12.83 0.358
PLT(109/L) 202.92 ± 83.81 198.50 ± 63.50 0.900
PT (s) 13.45 ± 1.32 12.59 ± 1.26 0.155
INR 1.04 ± 0.12 1.02 ± 0.96 0.631
Tumor size, mm 125.54 ± 25.78 127.13 ± 52.94 0.930
Cirrhosis, n (%) 76 (58.02) 29 (52.72) 0.507
Extent of resection 0.515
 Extended (≥ 4 segments) 84 (64.12) 38 (69.09)
 Partial (< 4 segments) 47 (35.88) 17 (30.91)
Conventional predictive models
 Child-Pugh scorea 5 (5–8) 5 (5–8) 0.463
 MELD scorea 7 (6–15) 7 (6–13) 0.568
 ALBI scoreb − 2.47 (− 0.51~− 3.42) − 2.55 (− 1.09~− 3.32) 1.000
Intraoperative blood loss, ml b 400 (200–800) 500 (300–800) 0.199
Intraoperative blood transfusion, n (%)
 Yes 87 (66.4%) 23 (41.8%) 0.002
 No 44 (33.6%) 32 (58.2%)  
Pringle maneuver, n (%)    0.872
 Yes 65 (49.6%) 28 (50.9%)  
 No 66 (50.4%) 27 (49.1%)  
PHLF (B/C), n (%)    0.293
 Yes 41 (31.30) 13 (23.64)
 No 90 (68.70) 42 (76.36)
Postoperative mortality, n (%) 5 (3.8%) 3 (5.4%) 0.696
  1. BMI body mass index, HBsAg hepatitis B surface antigen, AFP alpha fetoprotein, SD standard deviation, ALB albumin, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate transaminase, GGT γ-glutamyl transpeptidase, PLT platelets, PT prothrombin time, INR international normalized ratio, MELD model for end-stage liver disease, ALBI albumin to bilirubin ration index, PHLF posthepatectomy liver failure
  2. aMedian (range)
  3. bMedian (IQR)