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Table 1 Comparison of patient demographics and clinicopathological features of the two datasets

From: CT radiomics nomogram for the preoperative prediction of severe post-hepatectomy liver failure in patients with huge (≥ 10 cm) hepatocellular carcinoma

Variable

Training dataset

(n = 131)

Test dataset

(n = 55)

p value

Sex, n (%)

0.363

 Male

118 (90.08)

47 (85.46)

 Female

13 (9.92)

8 (14.54)

Age, years

58.69 ± 11.13

53.25 ± 17.19

0.387

BMI, kg/m2

23.97 ± 3.79

23.89 ± 4.01

0.963

HBsAg positive, n (%)

104 (79.38)

36 (65.45)

0.044

Child-Pugh class, n (%)

0.923

 A

115 (87.79)

48 (87.27)

 B

16(12.21)

7(12.72)

AFP, median (IQR), ng/ml

38.7 (4–3849)

171.5 (9–9312)

0.717

Liver function tests

 ALB (g/L)

38.07 ± 4.84

37.55 ± 6.57

0.837

 TBIL (μmol/L)

16.07 ± 8.75

18.94 ± 12.43

0.541

 ALT (U/L)

48.00 ± 53.05

58.88 ± 47.64

0.641

 AST (U/L)

81.23 ± 63.99

75.75 ± 66.02

0.853

 GGT(U/L)

130.62 ± 109.54

167.13 ± 166.12

0.549

 Cr (μmol/L)

50.46 ± 11.81

55.63 ± 12.83

0.358

PLT(109/L)

202.92 ± 83.81

198.50 ± 63.50

0.900

PT (s)

13.45 ± 1.32

12.59 ± 1.26

0.155

INR

1.04 ± 0.12

1.02 ± 0.96

0.631

Tumor size, mm

125.54 ± 25.78

127.13 ± 52.94

0.930

Cirrhosis, n (%)

76 (58.02)

29 (52.72)

0.507

Extent of resection

0.515

 Extended (≥ 4 segments)

84 (64.12)

38 (69.09)

 Partial (< 4 segments)

47 (35.88)

17 (30.91)

Conventional predictive models

 Child-Pugh scorea

5 (5–8)

5 (5–8)

0.463

 MELD scorea

7 (6–15)

7 (6–13)

0.568

 ALBI scoreb

− 2.47 (− 0.51~− 3.42)

− 2.55 (− 1.09~− 3.32)

1.000

Intraoperative blood loss, ml b

400 (200–800)

500 (300–800)

0.199

Intraoperative blood transfusion, n (%)

 Yes

87 (66.4%)

23 (41.8%)

0.002

 No

44 (33.6%)

32 (58.2%)

 

Pringle maneuver, n (%)

  

0.872

 Yes

65 (49.6%)

28 (50.9%)

 

 No

66 (50.4%)

27 (49.1%)

 

PHLF (B/C), n (%)

  

0.293

 Yes

41 (31.30)

13 (23.64)

 No

90 (68.70)

42 (76.36)

Postoperative mortality, n (%)

5 (3.8%)

3 (5.4%)

0.696

  1. BMI body mass index, HBsAg hepatitis B surface antigen, AFP alpha fetoprotein, SD standard deviation, ALB albumin, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate transaminase, GGT γ-glutamyl transpeptidase, PLT platelets, PT prothrombin time, INR international normalized ratio, MELD model for end-stage liver disease, ALBI albumin to bilirubin ration index, PHLF posthepatectomy liver failure
  2. aMedian (range)
  3. bMedian (IQR)