Table 1 Clinicopathological characteristics of the study cohort, in patients with locally advanced and highly advanced CRC
Characteristics | Locally advanced CRC (N = 91) | Highly advanced CRC (N = 209) | P value | |
|---|---|---|---|---|
Age (years), mean ± SD | 63.7 ± 6.7 | 63.4 ± 7.1 | 0.684 | |
Gender—female, n (%) | 48 (53%) | 91 (44%) | 0.149 | |
Tumor location | Proximal colon | 20 (22%) | 43 (21%) | 0.002 |
Transverse colon | 11 (12%) | 49 (23%) | ||
Distal colon | 31 (34%) | 87 (42%) | ||
Rectum | 29 (32%) | 28 (13%) | ||
Multifocal | 0 | 2 (1%) | ||
Tumor size (cm), mean ± SD | 2.58 ± 1.59 | 4.83 ± 2.36 | p<0.001 | |
Obstructing tumor | 1 (1.1%) | 56 (27%) | p<0.001 | |
Symptoms | Asymptomatic | 42 (46%) | 47 (22.5%) | p<0.001 |
Symptomatic | 49 (54%) | 162 (77.5%) | ||
CEA > 5 (ng/ml), n (%) | 5 (9%) | 47 (34%) | 0.0013 | |
HgB (g/dL), mean ± SD | 13.1 ± 1. 8 | 12.2 ± 2.2 | p<0.001 | |
Anemia, n (%) | 26 (28.6%) | 97 (46.4%) | 0.004 | |
Severe anemia, n (%) | 4 (4%) | 35 (17%) | 0.0021 | |