Fig. 9

The effect of CXCL10 on tumor and angiogenesis. A QRT-PCR verified the expression of CXCL10 mRNA. B Tumor size and volume in each treatment group. C Tumor tissue HE, KI67, TUNEL, and CD8⁺ cell staining results. We use Image J to quantitatively analyze the number of KI67, TUNEL, and CD8-positive cells, and all data are expressed in the form of mean + SEM. D, E MRNA and protein expression of angiogenesis markers (VEGFA, COX2, and CD34) in different treatments. F IHC scores of COX2 and VEGFA in tissues was compared with each group. MVD was calculated as the average measurement of 10 random high-power fields (20×). NC normal control group, si-NC inhibitor control group, si-CXCL10 suppress CXCL10 expression group, CXCL10 overexpression CXCL10 group, *p < 0.05 vs. NC group