Fig. 2

The Paget’s cell is characterized by large volume, rich and transparent cytoplasm, and the round, large hyperchromatic nuclei, with mitotic figures (A). Immunohistochemical analysis was positive in CDX-2 (B) and CK20 (C), which strongly suggested the possible origin of adenocarcinoma. Heteromorphic solid cell nests were observed in the hepatic penetrating tissues. Liver biopsy showed large cell body, little cytoplasm, hyperchromatic nuclei with distinct atypia, and the mitotic figures were visible, as well as intracellular mucous (D)