Table 3 Univariate and multivariate Cox regression of clinicopathological for overall survival

Age (< 60years)

0.012

1.754 (1.129–2.726)

Gender (male)

0.011

1.590 (1.112–2.272)

0.005

1.626 (1.133–2.335)

Tumor diameter (5 cm)

0.881

0.975 (0.669–1.360)

 Rectum

Refer

 Left colon

0.906

1.026 (0.673–1.562)

 Right colon

0.438

0.849 (0.561–1.284)

Pathological T stage

< 0.001

2.453 (1.477–4.074)

Lymph node metastasis

< 0.001

2.891 (2.058–4.060)

TNM stage

< 0.001

3.273 (2.305–4.649)

< 0.001

2.755 (1.887–4.022)

Tumor differentiation

0.002

1.775 (1.242–2.537)

Vessel invasion

< 0.001

1.925 (1.376–2.692)

Intraneural invasion

0.133

1.509 (0.882–2.584)

Tumor deposit

< 0.001

4.095 (2.724–6.156)

< 0.001

2.102 (1.351–3.270)

Bowel perforation

0.815

0.888 (0.328–2.401)

Tumor budding

< 0.001

1.856 (1.274–2.705)

Schistosomiasis

0.048

1.388 (0.994–1.940)

0.042

1.424 (1.016–1.996)

Ulceration

0.554

0.903 (0.644–1.266)

Histological type

0.521

1.168 (0.727–1.875)

CD8 density

< 0.001

0.424 (0.294–0.611)

0.010

0.635 (0.449–0.897)

sPD-L1

0.046

0.702 (0.496–0.993)

iPD-L1

0.540

0.637 (0.326–1.266)