A systematic review of proteomic biomarkers in oral squamous cell cancer

Table 3 Potential protein biomarkers of head and neck cancers: autoantibodies

Sample	Technique	Biomarker [accession no.]	Confirmation by	Biomarker for	Discussion	Reference
OSCC saliva	IHC	P53 autoantibody	ELISA; IHC	OSCC	p53 antibodies found only in serum and saliva of patients showing overexpression of p53 in their tumor tissues. Checks for overexpression of p53 protein however do not differentiate between wild and mutant proteins.	[125]
OSCC	MALDI-TOF/TOF-MS	Heat shock protein 70 (HSP70)	MS	Carcinogenesis	Cellular network of molecular chaperones and folding catalysts assists in protein folding process. Identified as early marker and prognostic marker in OSCC	[126]
OSCC	MALDI TOF-MS/2DE	Sideroflexin 3 (SFXN3)	MS	Response to therapy	Mitochondrial serine transporter participate in one-carbon metabolism pathway.	[127]

Note: IHC immunohistochemistry, WB western blot, ROC receiver operator characteristic analysis, KMS Kaplan-Meier survival analysis, iTRAQ isobaric tags for relative and absolute quantitation, RP reverse phase, OSCC oral squamous cell carcinoma

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