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Table 3 Multivariate analysis of prognostic factors of 294 patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

From: Unresected small lymph node assessment predicts prognosis for patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

Item

P

HR

95% CI

   

Lower

Upper

TR

 No. of removed LNs

  <15

 

Reference

  

  ≥15

0.065

0.708

0.491

1.022

 Tumor grade

0.033*

   

  Well-differentiated

 

Reference

  

  Moderately differentiated

0.368

1.253

0.767

2.050

  Poorly differentiated

0.016*

1.822

1.118

2.968

 Adjuvant therapy

<0.001*

   

  No

 

Reference

  

  Chemotherapy

<0.001*

0.466

0.318

0.681

  Radiotherapy/chemoradiotherapy

0.008*

0.349

0.160

0.763

 Unresected small LNs status

  CT-negative

 

Reference

  

  CT-suspect

0.001*

1.813

1.263

2.602

LR

 No. of removed LNs

  <15

 

Reference

  

  ≥15

0.061

0.665

0.434

1.019

 Tumor grade

0.017*

   

  Well-differentiated

 

Reference

  

  Moderately differentiated

0.046*

1.900

1.011

3.569

  Poorly differentiated

0.004*

2.510

1.334

4.723

 Adjuvant therapy

<0.001*

   

  No

 

Reference

  

  Chemotherapy

<0.001*

0.437

0.279

0.683

  Radiotherapy/chemoradiotherapy

0.009*

0.256

0.092

0.711

 Unresected small LNs status

  CT-negative

 

Reference

  

  CT-suspect

<0.001*

2.133

1.407

3.233

DM

 Adjuvant therapy

0.039*

   

  No

 

Reference

  

  Chemotherapy

0.011*

0.462

0.255

0.836

  Radiotherapy/chemoradiotherapy

0.423

0.675

0.259

1.764

OS

 No. of removed LNs

  <15

 

Reference

  

  ≥15

0.109

0.708

0.464

1.080

 Tumor grade

0.043*

   

  Well-differentiated

 

Reference

  

  Moderately differentiated

0.565

1.181

0.670

2.083

  Poorly differentiated

0.028*

1.878

1.070

3.296

 Adjuvant therapy

0.010*

   

  No

 

Reference

  

  Chemotherapy

0.003*

0.516

0.332

0.803

  Radiotherapy/chemoradiotherapy

0.158

0.564

0.255

1.248

 Unresected small LNs status

  CT-negative

 

Reference

  

  CT-suspect

0.005*

1.807

1.192

2.740

  1. TR total recurrence; LR locoregional recurrence; DM distant metastasis; OS overall survival; CT computed tomography; LN lymph node
  2. *P value < 0.05