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Table 3 Multivariate analysis of prognostic factors of 294 patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

From: Unresected small lymph node assessment predicts prognosis for patients with pT3N0M0 thoracic esophageal squamous cell carcinoma

Item P HR 95% CI
    Lower Upper
TR
 No. of removed LNs
  <15   Reference   
  ≥15 0.065 0.708 0.491 1.022
 Tumor grade 0.033*    
  Well-differentiated   Reference   
  Moderately differentiated 0.368 1.253 0.767 2.050
  Poorly differentiated 0.016* 1.822 1.118 2.968
 Adjuvant therapy <0.001*    
  No   Reference   
  Chemotherapy <0.001* 0.466 0.318 0.681
  Radiotherapy/chemoradiotherapy 0.008* 0.349 0.160 0.763
 Unresected small LNs status
  CT-negative   Reference   
  CT-suspect 0.001* 1.813 1.263 2.602
LR
 No. of removed LNs
  <15   Reference   
  ≥15 0.061 0.665 0.434 1.019
 Tumor grade 0.017*    
  Well-differentiated   Reference   
  Moderately differentiated 0.046* 1.900 1.011 3.569
  Poorly differentiated 0.004* 2.510 1.334 4.723
 Adjuvant therapy <0.001*    
  No   Reference   
  Chemotherapy <0.001* 0.437 0.279 0.683
  Radiotherapy/chemoradiotherapy 0.009* 0.256 0.092 0.711
 Unresected small LNs status
  CT-negative   Reference   
  CT-suspect <0.001* 2.133 1.407 3.233
DM
 Adjuvant therapy 0.039*    
  No   Reference   
  Chemotherapy 0.011* 0.462 0.255 0.836
  Radiotherapy/chemoradiotherapy 0.423 0.675 0.259 1.764
OS
 No. of removed LNs
  <15   Reference   
  ≥15 0.109 0.708 0.464 1.080
 Tumor grade 0.043*    
  Well-differentiated   Reference   
  Moderately differentiated 0.565 1.181 0.670 2.083
  Poorly differentiated 0.028* 1.878 1.070 3.296
 Adjuvant therapy 0.010*    
  No   Reference   
  Chemotherapy 0.003* 0.516 0.332 0.803
  Radiotherapy/chemoradiotherapy 0.158 0.564 0.255 1.248
 Unresected small LNs status
  CT-negative   Reference   
  CT-suspect 0.005* 1.807 1.192 2.740
  1. TR total recurrence; LR locoregional recurrence; DM distant metastasis; OS overall survival; CT computed tomography; LN lymph node
  2. *P value < 0.05